{"id":"W4405695730","doi":"10.1016/j.jaad.2024.12.018","title":"Efficacy and safety of tildrakizumab for the treatment of moderate-to-severe plaque psoriasis of the scalp: Week 52 results from a phase 3b, randomized, double-blind, placebo-controlled trial","year":2024,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Sun Pharma; Amgen","keywords":"Medicine; Scalp; Randomized controlled trial; Placebo; Double blind; Dermatology; Psoriasis; Adverse effect; Surgery; Internal medicine; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002364616,0.001107962,0.001990008,0.000275319,0.0003956913,0.0009966053,0.0006881888,0.001446807,0.006868769],"category_scores_gemma":[0.001592019,0.0004445924,0.001867705,0.0002703222,0.0006081635,0.0006771523,0.0002602313,0.002216619,0.001194072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005581822,"about_ca_system_score_gemma":0.0007547252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004426337,"about_ca_topic_score_gemma":0.001161915,"domain_scores_codex":[0.9990576,0.000459371,0.00008143453,0.0001695936,0.0001151796,0.0001167781],"domain_scores_gemma":[0.9990603,0.0001931153,0.0003656999,0.00008476981,0.00007442838,0.0002216453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9159862,0.01020805,0.002022539,0.002248957,0.002071018,0.0001054905,0.0001029786,0.0003925419,0.0181805,0.0001042175,0.002644277,0.04593328],"study_design_scores_gemma":[0.9317736,0.05531077,0.009024463,0.0001352663,0.0008884924,0.0001244549,0.00001617556,0.0002994752,0.001151111,0.0001131093,0.001142743,0.00002036818],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717507,0.01514122,0.001040802,0.0009451123,0.0003523845,0.004684327,0.001607313,0.0002673358,0.004210723],"genre_scores_gemma":[0.9859897,0.004123569,0.001226162,0.00129102,0.0002923539,0.003259982,0.001247421,0.00004084555,0.002528955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006868769,"threshold_uncertainty_score":0.02297837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02970217914875858,"score_gpt":0.3124346917969693,"score_spread":0.2827325126482107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}