{"id":"W4405700561","doi":"10.3390/pathogens13121137","title":"Enhancement of Human Immunodeficiency Virus-Specific CD8+ T Cell Responses with TIGIT Blockade Involves Trogocytosis","year":2024,"lang":"en","type":"article","venue":"Pathogens","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research","keywords":"TIGIT; Cytotoxic T cell; CD8; Degranulation; Immunology; T cell; Flow cytometry; Antibody; Biology; Receptor; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319132,0.0004390428,0.0003532047,0.0001626402,0.0001194562,0.0003285924,0.0002408364,0.0002854956,0.001329508],"category_scores_gemma":[0.0001500842,0.0001323675,0.000247629,0.0001274716,0.0002183341,0.0001955633,0.0002145651,0.000894213,0.0003439724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002367885,"about_ca_system_score_gemma":0.0001799839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003441786,"about_ca_topic_score_gemma":0.0005533145,"domain_scores_codex":[0.9998053,0.00003061494,0.00001847283,0.00003691846,0.00003747917,0.00007128833],"domain_scores_gemma":[0.9999257,0.00001933595,0.00001637513,0.00001220085,0.000007580551,0.00001872611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001917638,0.0000762205,0.0003354865,0.00003827231,0.000006872936,0.00006061941,0.00001916767,0.00008538799,0.9964817,0.0000425272,0.00004579583,0.002616292],"study_design_scores_gemma":[0.00007110372,0.002325552,0.009917068,0.0000132495,0.00002720738,0.0007446061,0.00003177318,0.0009844247,0.9834396,0.00006130202,0.00237856,0.000005501703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962107,0.001205032,0.0008873328,0.00004717871,0.00001570065,0.00004807987,0.0001001456,0.00005603107,0.0014298],"genre_scores_gemma":[0.9971066,0.0006130398,0.000942521,0.00006171026,0.00001160699,0.00006908138,0.0001808135,0.00001018094,0.001004361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001329508,"threshold_uncertainty_score":0.004447639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0195087060986892,"score_gpt":0.2437313651040698,"score_spread":0.2242226590053806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}