{"id":"W4405719349","doi":"10.1371/journal.ppat.1012786","title":"Systematic assessment of COVID-19 host genetics using whole genome sequencing data","year":2024,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"European Research Council; Heidelberger Zentrum für Personalisierte Onkologie Deutsches Krebsforschungszentrum In Der Helmholtz-Gemeinschaft; Land Nordrhein-Westfalen; College of Medicine Office of Research, Ohio State University; Provincia autonoma di Bolzano - Alto Adige; Stiftung Universitätsmedizin Essen; Medizinische Fakultät, Rheinische Friedrich-Wilhelms-Universität Bonn; RWTH Aachen University; Rheinische Friedrich-Wilhelms-Universität Bonn; Technische Universität München; Bundesministerium für Bildung und Forschung; Illumina; Care-for-Rare Foundation; Deutsche Forschungsgemeinschaft","keywords":"Biology; Locus (genetics); Genetics; Genome-wide association study; Genetic variation; Population; Genome; Cohort; Gene; Medicine; Single-nucleotide polymorphism; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006047725,0.0001840107,0.0004430047,0.0001952133,0.0001263771,0.00003914217,0.0005011842,0.0001552436,0.0003194165],"category_scores_gemma":[0.0002874265,0.0001556769,0.000091375,0.0001703695,0.0001282232,0.00008631015,0.0003637024,0.0002204703,0.0002115198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002675484,"about_ca_system_score_gemma":0.000767177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003143918,"about_ca_topic_score_gemma":0.000006116581,"domain_scores_codex":[0.9982289,0.0004879479,0.0005386124,0.0003756689,0.00006801956,0.0003008275],"domain_scores_gemma":[0.9985539,0.0003156402,0.0001275853,0.0009043834,0.00006085872,0.00003758504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001474266,0.00004897662,0.0000931894,0.006862602,0.0005097867,0.00005313876,0.0007115867,0.00005590428,0.9913837,0.000162418,0.00008648179,0.00001751494],"study_design_scores_gemma":[0.002901082,0.00177752,0.001635264,0.02961077,0.005728323,0.003408334,0.01451899,0.07581541,0.8292252,0.0001752697,0.03259024,0.002613644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9340661,0.05258265,0.008893152,0.0001420365,0.0008591715,0.0007330561,0.002230338,0.0001587454,0.0003347539],"genre_scores_gemma":[0.9973032,0.000284617,0.001023577,0.0001385741,0.00003133153,0.00001461804,0.000421522,0.00003599493,0.0007465256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1621585,"threshold_uncertainty_score":0.6348321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1021982198614527,"score_gpt":0.3457398280597644,"score_spread":0.2435416081983117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}