{"id":"W4405729079","doi":"10.1152/ajpheart.00438.2024","title":"BRD4 inhibition rewires cardiac macrophages toward a protective phenotype marked by low MHC class II expression","year":2024,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Roy and Christine Sturgis Charitable Trust; American Heart Association","keywords":"BRD4; Cell biology; Bromodomain; Chemokine; Biology; Proinflammatory cytokine; Gene knockdown; CCL7; Gene expression; Major histocompatibility complex; Inflammation; MHC class I; Chromatin; Cancer research; Immune system; Immunology; Epigenetics; CXCL10; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002855007,0.0003051718,0.001076593,0.0002824097,0.0001898741,0.00002043428,0.00007667853,0.0001558496,0.0002366334],"category_scores_gemma":[0.00005862844,0.0002367762,0.0004845882,0.0003991604,0.0008609572,0.0001939731,0.00008033747,0.0006695093,0.00002579946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009621729,"about_ca_system_score_gemma":0.0001798086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002623429,"about_ca_topic_score_gemma":3.816422e-7,"domain_scores_codex":[0.9978948,0.0004144901,0.0005429846,0.000532681,0.0002401447,0.0003749171],"domain_scores_gemma":[0.9988207,0.0001204892,0.0003218655,0.0002541358,0.0002262665,0.0002566075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004778799,0.0001673111,0.00007715124,0.0001755527,0.0003658704,0.000006467985,0.0004146698,0.00001310974,0.9876515,0.00003419924,0.009494245,0.00112204],"study_design_scores_gemma":[0.003281851,0.008120104,0.5590006,0.00382353,0.001006171,0.0005434334,0.003242653,0.001159871,0.3974516,0.003956171,0.01719283,0.001221166],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996262,0.001791453,0.00001788233,0.001355572,0.0001801081,0.0002091802,0.00003843767,0.00006181473,0.00008361333],"genre_scores_gemma":[0.9976437,0.0002012733,0.0001074941,0.001197428,0.0006653805,0.00002260111,0.00004859782,0.00003753002,0.00007599926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5901999,"threshold_uncertainty_score":0.9655455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007808502358706174,"score_gpt":0.2503497707183029,"score_spread":0.2425412683595968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}