{"id":"W4405729079","doi":"10.1152/ajpheart.00438.2024","title":"BRD4 inhibition rewires cardiac macrophages toward a protective phenotype marked by low MHC class II expression","year":2024,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Roy and Christine Sturgis Charitable Trust; American Heart Association","keywords":"BRD4; Cell biology; Bromodomain; Chemokine; Biology; Proinflammatory cytokine; Gene knockdown; CCL7; Gene expression; Major histocompatibility complex; Inflammation; MHC class I; Chromatin; Cancer research; Immune system; Immunology; Epigenetics; CXCL10; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002214248,0.000533022,0.0004009742,0.0004444768,0.0002217948,0.0003893512,0.000314575,0.0004158444,0.003234845],"category_scores_gemma":[0.0001315256,0.0002213398,0.0004719305,0.0001994227,0.0003937067,0.0002279635,0.0002101133,0.001210129,0.0007556821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003974013,"about_ca_system_score_gemma":0.0003905283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005449145,"about_ca_topic_score_gemma":0.001168392,"domain_scores_codex":[0.9997632,0.00003353874,0.00002383494,0.0000467469,0.00005392936,0.00007882226],"domain_scores_gemma":[0.9998901,0.00000770041,0.00003102809,0.000009450598,0.00001017,0.00005163196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008894918,0.0001137054,0.0001950786,0.00009947053,0.00001835101,0.00005802026,0.00001030957,0.00007370405,0.9954211,0.0001486532,0.0003334626,0.002638588],"study_design_scores_gemma":[0.0002090305,0.001029723,0.004104737,0.0000161375,0.00003906482,0.0002728961,0.00004516098,0.0006307873,0.9870852,0.00007576187,0.006481517,0.000009976194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976348,0.005859436,0.006462931,0.0009408497,0.0004195769,0.0001438803,0.003550968,0.000563197,0.005711072],"genre_scores_gemma":[0.9794217,0.002374171,0.00518095,0.0003259126,0.00003800961,0.0001641186,0.002678209,0.00008212112,0.009734692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003234845,"threshold_uncertainty_score":0.01082158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007808502358706174,"score_gpt":0.2503497707183029,"score_spread":0.2425412683595968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}