{"id":"W4405735583","doi":"10.1113/jp286699","title":"Medial hypothalamic MC3R signalling regulates energy rheostasis in adult mice","year":2024,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Hamilton Health Sciences; University of Illinois at Urbana-Champaign; National Institutes of Health; Foundation for Prader-Willi Research; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Brain and Behavior Research Foundation","keywords":"Energy homeostasis; Orexigenic; Melanocortin; Biology; Hypothalamus; Internal medicine; Melanocortin 3 receptor; Endocrinology; Neuroscience; Receptor; Neuropeptide; Melanocortin receptor; Neuropeptide Y receptor; Medicine; Genetics; Obesity; Hormone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002778094,0.0006373306,0.000404025,0.001146921,0.0003345394,0.0005437277,0.000557795,0.0007132371,0.003475457],"category_scores_gemma":[0.0001611539,0.0004809728,0.0005400798,0.0002525816,0.0007151503,0.0003915193,0.0004038593,0.001402913,0.001210154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006874258,"about_ca_system_score_gemma":0.000376037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026846,"about_ca_topic_score_gemma":0.002350124,"domain_scores_codex":[0.9996124,0.00003412133,0.00003437944,0.000121395,0.0001071084,0.00009057223],"domain_scores_gemma":[0.9995623,0.0000302041,0.0001917982,0.00004331814,0.00003001791,0.0001422678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000271177,0.00003641373,0.0001844024,0.00001871152,0.00000438592,0.00007359663,0.00002794188,0.00002929974,0.9980834,0.0001628578,0.00004919636,0.001058681],"study_design_scores_gemma":[0.0002215479,0.0006817424,0.02481693,0.00004602211,0.00004915436,0.001017941,0.0001422019,0.001152885,0.9652398,0.0003592307,0.006248585,0.00002407662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875451,0.001637133,0.0047693,0.0003705839,0.00006658519,0.00007769283,0.002657193,0.0004226461,0.002453731],"genre_scores_gemma":[0.9695237,0.001544269,0.0103266,0.0004032388,0.0000513439,0.0003141499,0.002408804,0.0004634894,0.01496438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003475457,"threshold_uncertainty_score":0.01162654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01716801113999114,"score_gpt":0.2482857155866786,"score_spread":0.2311177044466874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}