{"id":"W4405743098","doi":"10.1016/j.celrep.2024.115102","title":"Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responses","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research; Canada First Research Excellence Fund; Canada Excellence Research Chairs, Government of Canada; Canada Foundation for Innovation; Canadian Blood Services; Natural Sciences and Engineering Research Council of Canada; Toronto General and Western Hospital Foundation","keywords":"Cell; Graft-versus-host disease; Cell therapy; Disease; Immunology; T cell; Biology; Medicine; Immune system; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001772234,0.0004831282,0.0002850072,0.0002502984,0.0001486586,0.0004746692,0.0001614924,0.0003075184,0.002037962],"category_scores_gemma":[0.00009577371,0.00008298834,0.0001913906,0.0001514117,0.0002750493,0.0001749199,0.0002132406,0.001105427,0.0005627611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002137123,"about_ca_system_score_gemma":0.0002703379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002608643,"about_ca_topic_score_gemma":0.0009186254,"domain_scores_codex":[0.9998314,0.00002873621,0.00001040388,0.00002772541,0.00005590026,0.00004582754],"domain_scores_gemma":[0.9999076,0.00001562593,0.0000238644,0.00001436837,0.000008074883,0.00003042852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002516823,0.0001844663,0.0003415643,0.00006694622,0.00001068757,0.0000451223,0.00002466351,0.0002618083,0.9927405,0.0002038039,0.0003755155,0.005493217],"study_design_scores_gemma":[0.0001191947,0.002053284,0.002794247,0.00002301312,0.00004844828,0.0003939577,0.00004785422,0.001891016,0.973245,0.0001294448,0.01924567,0.000008828307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825159,0.003905292,0.007272306,0.0003643745,0.0001907505,0.0001473636,0.0005826289,0.0002488776,0.004772343],"genre_scores_gemma":[0.9881369,0.001906959,0.004254835,0.0002788262,0.00005854321,0.0001348196,0.0008001916,0.00004021207,0.004388602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002037962,"threshold_uncertainty_score":0.006817698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01991404381138202,"score_gpt":0.2377411180670187,"score_spread":0.2178270742556367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}