{"id":"W4405762511","doi":"10.1002/anie.202419736","title":"Probing the Protein Kinases′ Cysteinome by Covalent Fragments","year":2024,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Structural Genomics Consortium; Deutschen Konsortium für Translationale Krebsforschung; Fonds der Chemischen Industrie; Deutsche Krebshilfe; Deutsche Forschungsgemeinschaft; Baden-Württemberg Stiftung","keywords":"Kinase; Covalent bond; Chemistry; Cell biology; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003617511,0.0005775858,0.0003150633,0.0002847948,0.0002041808,0.0002850501,0.0003394246,0.0003123179,0.001092819],"category_scores_gemma":[0.0002523532,0.0001849039,0.0003081885,0.0003619282,0.0002923233,0.0002668147,0.0003158928,0.0005783144,0.000453084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003939357,"about_ca_system_score_gemma":0.0002643641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006327939,"about_ca_topic_score_gemma":0.001479505,"domain_scores_codex":[0.9997717,0.00002549243,0.00001135123,0.00005510405,0.00009165385,0.00004483372],"domain_scores_gemma":[0.9999017,0.00002303305,0.00002712939,0.00001760204,0.00001917648,0.00001127599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004753148,0.00002162428,0.0002024417,0.00008817065,0.0000154504,0.00004419378,0.00001443967,0.0002552819,0.993602,0.0001712656,0.0001210969,0.0054166],"study_design_scores_gemma":[0.000006369899,0.0002447407,0.0006254873,0.000004146072,0.00001539084,0.0001298719,0.000008351821,0.0003170865,0.9959071,0.00004426679,0.002693074,0.000004028683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9175331,0.0083634,0.06323089,0.0003243959,0.00006190631,0.0003559704,0.001888998,0.0005978087,0.007643527],"genre_scores_gemma":[0.9605765,0.006000557,0.02591391,0.0002515732,0.00002270914,0.0001772518,0.001687057,0.00006409396,0.005306378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001092819,"threshold_uncertainty_score":0.003655851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01399151189500215,"score_gpt":0.274083775046495,"score_spread":0.2600922631514929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}