{"id":"W4405762763","doi":"10.1101/2024.12.21.629933","title":"Spatiotemporal photocatalytic proximity labeling proteomics reveals ligand-activated extracellular and intracellular EGFR neighborhoods","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Francisco; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; James B. Pendleton Charitable Trust; National Heart, Lung, and Blood Institute; Gladstone Institutes","keywords":"Internalization; Interactome; Epidermal growth factor receptor; Cell biology; Phosphorylation; Extracellular; Proteomics; Intracellular; Signal transduction; Cell signaling; Cell; Chemistry; Receptor; Biology; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001411065,0.0001564374,0.0001562504,0.0002030119,0.0001644007,0.0004078504,0.0001897078,0.0002931162,0.0008822116],"category_scores_gemma":[0.0001346027,0.0001547439,0.0001405887,0.0001711991,0.0002500022,0.0003006932,0.000335551,0.0004302631,0.0002489964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003768954,"about_ca_system_score_gemma":0.0001640476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001098589,"about_ca_topic_score_gemma":0.001515692,"domain_scores_codex":[0.9999009,0.000006571027,0.000003627039,0.00003854144,0.00002759391,0.00002283392],"domain_scores_gemma":[0.9999338,0.0000177662,0.00001967833,0.000009082172,0.000009809368,0.00000990431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002271058,0.000005650997,0.0002179242,0.00001392233,0.000002122481,0.00002267712,0.00001526749,0.0001589668,0.998118,0.0001358485,0.00005252814,0.001234413],"study_design_scores_gemma":[0.000004183297,0.00002377858,0.00318004,0.000001788736,0.00000342282,0.00006854107,0.00003232326,0.003550393,0.992273,0.00008822494,0.0007696867,0.000004707491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779484,0.0003651282,0.01955039,0.000108972,0.00001197072,0.00001905159,0.000308358,0.0001678993,0.001519742],"genre_scores_gemma":[0.9774029,0.000398079,0.01916794,0.00007378864,0.000008420207,0.00004279503,0.000237243,0.00005162337,0.002617243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001098589,"threshold_uncertainty_score":0.002951264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049106944185853,"score_gpt":0.2188732676471878,"score_spread":0.2083821982053292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}