{"id":"W4405762867","doi":"10.1101/2024.12.17.628646","title":"ABHD2 activity is not required for the non-genomic action of progesterone on human sperm","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Deutsche Forschungsgemeinschaft; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Genentech; Bayer; Bill and Melinda Gates Foundation; Pfizer; Ontario Genomics; Genome Canada","keywords":"Sperm; Activator (genetics); Mechanism of action; Chemistry; Sperm motility; Biological activity; Oviduct; Motility; Internal medicine; Cell biology; In vitro; Endocrinology; Biology; Pharmacology; Receptor; Biochemistry; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001030465,0.0001396213,0.0002165044,0.00007575059,0.0001291174,0.0002593332,0.0001082191,0.0002025778,0.002827201],"category_scores_gemma":[0.0001980127,0.00008475404,0.0001878438,0.00008054171,0.0001838783,0.0001255049,0.000111585,0.0002393616,0.0004645178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002364239,"about_ca_system_score_gemma":0.0002796513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006643618,"about_ca_topic_score_gemma":0.0008365219,"domain_scores_codex":[0.9998934,0.00001733368,0.00001034407,0.00002521194,0.00003412943,0.0000195506],"domain_scores_gemma":[0.9999065,0.00002211845,0.0000295058,0.00001291011,0.00001138594,0.00001747498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003020767,0.00001559314,0.0005933872,0.00008458287,0.000008768355,0.0001198728,0.00001171621,0.00009109716,0.9967583,0.0001002187,0.00005681491,0.001857559],"study_design_scores_gemma":[0.00002294644,0.0003937833,0.007807996,0.000007020595,0.00001852572,0.0005918727,0.00002333637,0.0003824029,0.9857859,0.00003110325,0.00493088,0.000004247608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868879,0.005999675,0.003404175,0.0001677058,0.00003904048,0.00006460845,0.000792401,0.00005656075,0.002588023],"genre_scores_gemma":[0.9957952,0.0008524231,0.0009499877,0.00003984584,0.000009002931,0.00001619568,0.0006031261,0.000006077576,0.001728154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002827201,"threshold_uncertainty_score":0.009457946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0564375503333286,"score_gpt":0.2965411802848955,"score_spread":0.2401036299515669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}