{"id":"W4405765238","doi":"10.1093/cercor/bhae480","title":"Identification of <i>Pappa</i> and <i>Sall3</i> as Gli3 direct target genes acting downstream of cilia signaling in corticogenesis","year":2024,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Simons Initiative for the Developing Brain; Simons Foundation Autism Research Initiative","keywords":"GLI3; Corticogenesis; Cilium; Biology; Homeobox; Hedgehog signaling pathway; Transcription factor; Enhancer; Cell biology; Neuroscience; Signal transduction; Gene; Genetics; Repressor; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008554801,0.0002609777,0.0001692775,0.0002739755,0.0001531546,0.0002380775,0.0001971134,0.0002121451,0.0007787736],"category_scores_gemma":[0.00007949815,0.0001352778,0.0002667539,0.0001123747,0.0003600846,0.0001303632,0.0002824926,0.0004127485,0.0003032786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002877204,"about_ca_system_score_gemma":0.0002864611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008559488,"about_ca_topic_score_gemma":0.001265652,"domain_scores_codex":[0.9999232,0.000006032671,0.000005161258,0.00002222822,0.00002456812,0.00001884506],"domain_scores_gemma":[0.9999123,0.00001088571,0.00002989113,0.000007861738,0.000008256673,0.00003084162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003078863,0.000002464003,0.0003852668,0.00001269195,0.000001413794,0.00006382533,0.000007146984,0.00003016848,0.9987797,0.00009011972,0.000013645,0.0005827221],"study_design_scores_gemma":[0.00000489222,0.00004106046,0.02575003,0.000005200714,0.00001278817,0.0005835159,0.00004148888,0.001036401,0.9707958,0.0001415541,0.001581328,0.000005961829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98737,0.0009273584,0.00901738,0.0001894871,0.0000168475,0.00002031588,0.0008309319,0.0001842373,0.001443604],"genre_scores_gemma":[0.9930715,0.0004178957,0.003916536,0.00007975976,0.000006072222,0.00001939026,0.0005493177,0.00003656407,0.001902963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008559488,"threshold_uncertainty_score":0.0026052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005409134522037961,"score_gpt":0.2356718154164933,"score_spread":0.2302626808944553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}