{"id":"W4405790898","doi":"10.1080/14740338.2024.2447072","title":"Is Duchenne gene therapy a suitable treatment despite its immunogenic class effect?","year":2024,"lang":"en","type":"review","venue":"Expert Opinion on Drug Safety","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Duchenne muscular dystrophy; Genetic enhancement; Weakness; Cardiomyopathy; Intensive care medicine; Disease; Bioinformatics; Internal medicine; Gene; Surgery; Heart failure; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004487744,0.0002998504,0.0006767871,0.0005237383,0.000173798,0.0007472379,0.0004994965,0.001248586,0.006093018],"category_scores_gemma":[0.0007925791,0.0000930844,0.000416405,0.0003809201,0.0004065239,0.0007285425,0.0002893799,0.001817031,0.002509801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000495387,"about_ca_system_score_gemma":0.0006423573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006118614,"about_ca_topic_score_gemma":0.001447756,"domain_scores_codex":[0.9998011,0.00004394023,0.00002038311,0.00003960473,0.0000762573,0.0000187688],"domain_scores_gemma":[0.9997539,0.0001192169,0.0000375382,0.000007165754,0.00006329164,0.00001886312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000107385,0.00004285128,0.0001168132,0.01093419,0.00008339759,0.0003151615,0.00005560528,0.0001880387,0.003336483,0.006992514,0.07689155,0.900936],"study_design_scores_gemma":[0.00002129741,0.00007566027,0.0002698325,0.002787115,0.00005032928,0.00111869,0.00003079749,0.00004737128,0.0006200197,0.00183523,0.9931339,0.000009829492],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003426035,0.9893624,0.0004592214,0.004440834,0.001309558,0.000009964987,0.00005981656,0.00002032249,0.003995386],"genre_scores_gemma":[0.003621045,0.9862059,0.000520954,0.003840811,0.001184587,0.0000189015,0.0001203163,0.000009409789,0.004478042],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006093018,"threshold_uncertainty_score":0.02038318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03765620373132751,"score_gpt":0.3601707511843166,"score_spread":0.3225145474529891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}