{"id":"W4405790898","doi":"10.1080/14740338.2024.2447072","title":"Is Duchenne gene therapy a suitable treatment despite its immunogenic class effect?","year":2024,"lang":"en","type":"review","venue":"Expert Opinion on Drug Safety","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Duchenne muscular dystrophy; Genetic enhancement; Weakness; Cardiomyopathy; Intensive care medicine; Disease; Bioinformatics; Internal medicine; Gene; Surgery; Heart failure; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002428279,0.0008657455,0.001193389,0.0001128312,0.0001842858,0.00003693461,0.000418675,0.0007080895,0.0001718468],"category_scores_gemma":[0.00002566159,0.0005982585,0.001208549,0.0001900072,0.00007301885,0.000004939222,0.0001547947,0.0002912587,0.0005503546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001444245,"about_ca_system_score_gemma":0.0003083772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002807203,"about_ca_topic_score_gemma":0.000002573898,"domain_scores_codex":[0.9972069,0.0004550931,0.0005357164,0.001121258,0.0001573556,0.0005236376],"domain_scores_gemma":[0.9985752,0.00007605802,0.0001846815,0.0009927887,0.00003965673,0.0001316682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007461732,0.0003704455,0.000001398823,0.001161409,0.001882106,0.000006537232,0.0002545247,0.00000443689,0.00376877,0.00008893165,0.03022662,0.9614887],"study_design_scores_gemma":[0.000948058,0.00114083,0.000003002463,0.001005612,0.00005991121,0.00001493774,0.0000132805,0.000004758893,0.006134792,0.0000096899,0.9900754,0.0005896947],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003112969,0.9956963,0.000007671462,0.0002056022,0.001616334,0.001181792,0.0001989101,0.00005487594,0.0007271811],"genre_scores_gemma":[0.0002140535,0.992101,0.00002115884,0.0005354487,0.0009269997,0.0006986993,0.002511333,0.0001334442,0.002857826],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9608989,"threshold_uncertainty_score":0.9996469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03765620373132751,"score_gpt":0.3601707511843166,"score_spread":0.3225145474529891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}