{"id":"W4405791908","doi":"10.21203/rs.3.rs-5132637/v1","title":"Unleashing the Immune Arsenal: Development of Broad-spectrum Multiepitope Bluetongue Vaccine Targeting Conserved T Cell Epitopes of Structural Proteins","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Vector-Borne Animal Diseases","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Faculty of Medicine, Dalhousie University; Canadian Institutes of Health Research; Dalhousie University","keywords":"Epitope; Virology; Biology; Immune system; Antibody; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000274122,0.0002221754,0.0001869301,0.0001147619,0.0001187631,0.0003291094,0.0001389342,0.0003455774,0.001674666],"category_scores_gemma":[0.0002164117,0.00009340903,0.00009665033,0.00008360288,0.0002042355,0.0004241839,0.0002751789,0.0004978561,0.0003288281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001663987,"about_ca_system_score_gemma":0.0001889842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003092631,"about_ca_topic_score_gemma":0.0004011291,"domain_scores_codex":[0.9999431,0.00001126539,0.000001401951,0.000009280513,0.00002068085,0.00001423972],"domain_scores_gemma":[0.9999672,0.000008502436,0.000003412711,0.000003249018,0.000005816322,0.00001175059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005453607,0.00009300705,0.0004687984,0.0002160994,0.00002513631,0.0002847457,0.00009391888,0.00347867,0.9315763,0.008452076,0.003300742,0.05146517],"study_design_scores_gemma":[0.0002136388,0.0007994112,0.002155031,0.00003545476,0.00004209258,0.0008903774,0.000129205,0.03007258,0.8915488,0.01564707,0.0584467,0.00001965084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9025989,0.01554791,0.06554983,0.005304445,0.0008456628,0.00005899628,0.0001732716,0.000237321,0.009683767],"genre_scores_gemma":[0.9544445,0.005875077,0.02158299,0.0006315851,0.0001610967,0.00002024612,0.0002968531,0.00007285264,0.01691483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001674666,"threshold_uncertainty_score":0.005602241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04687836759545184,"score_gpt":0.3176783936257584,"score_spread":0.2708000260303066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}