{"id":"W4405795210","doi":"10.1002/jcsm.13682","title":"Intrinsic Muscle Stem Cell Dysfunction Contributes to Impaired Regeneration in the <i>mdx</i> Mouse","year":2024,"lang":"en","type":"article","venue":"Journal of Cachexia Sarcopenia and Muscle","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Université du Québec à Chicoutimi; University of British Columbia; Ottawa Hospital; University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Stem Cell Network","keywords":"Duchenne muscular dystrophy; Medicine; Cardiotoxin; mdx mouse; Skeletal muscle; Dystrophin; Muscular dystrophy; Muscle hypertrophy; Myocyte; Internal medicine; Regeneration (biology); Pathology; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000268711,0.0006793028,0.0004432666,0.001225132,0.0002830545,0.0005249605,0.0003477165,0.0008646881,0.003456788],"category_scores_gemma":[0.0001491919,0.0003871012,0.0005321261,0.0002645149,0.0005588265,0.0002995886,0.0004055738,0.001151992,0.0008830312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004543146,"about_ca_system_score_gemma":0.0002340215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000817858,"about_ca_topic_score_gemma":0.001214987,"domain_scores_codex":[0.9996698,0.00002779569,0.0000475038,0.0001066272,0.00009277405,0.00005542571],"domain_scores_gemma":[0.9994726,0.00005167019,0.0002149662,0.00004151682,0.00003483201,0.0001845943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002007039,0.00005466049,0.0008039856,0.00003916932,0.0000094886,0.0001845244,0.00002881216,0.00007694894,0.9973864,0.0001519675,0.00009919754,0.0009640912],"study_design_scores_gemma":[0.0001014013,0.001349565,0.05865471,0.00007805019,0.00008494857,0.002581316,0.0002303221,0.001747187,0.9296861,0.0002718702,0.005179619,0.00003494081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921173,0.0009861386,0.00232995,0.0002000393,0.00003259136,0.00004574748,0.002618203,0.000242835,0.001427192],"genre_scores_gemma":[0.9801577,0.0009361505,0.003340489,0.0002648599,0.00002590984,0.0001792209,0.003007783,0.0002074793,0.01188048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003456788,"threshold_uncertainty_score":0.01156414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008363871810504925,"score_gpt":0.2299263215439235,"score_spread":0.2215624497334186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}