{"id":"W4405795246","doi":"10.1101/2024.12.23.630203","title":"APOE4 Increases Susceptibility to Amyloid, Accelerating Episodic Memory Decline","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Episodic memory; Amyloid (mycology); Psychology; Cognitive psychology; Neuroscience; Medicine; Cognition; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004147575,0.000396447,0.0002695784,0.0004199206,0.0001331437,0.0004943732,0.0001892711,0.0003643757,0.001401006],"category_scores_gemma":[0.0007116907,0.0001525669,0.0006510898,0.0003338385,0.0001863018,0.0002342202,0.0003397736,0.0002204825,0.0002043235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003046086,"about_ca_system_score_gemma":0.0002421372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004440259,"about_ca_topic_score_gemma":0.002444964,"domain_scores_codex":[0.9998779,0.00003706034,0.00001010664,0.00003065088,0.00001680004,0.00002737385],"domain_scores_gemma":[0.9997646,0.00005534339,0.0001189562,0.00002277844,0.00001722167,0.0000211018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004933773,0.0008429773,0.7798703,0.0002489535,0.001435995,0.001341515,0.0002894766,0.02339341,0.1441535,0.00157117,0.0007132096,0.04120563],"study_design_scores_gemma":[0.0001743638,0.002436789,0.9261647,0.00005914375,0.001107936,0.00143748,0.0002173493,0.03347678,0.02643316,0.004923084,0.003524414,0.00004470881],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998218,0.0003653157,0.0008335194,0.00002947604,0.000003656556,0.000005746576,0.0001493547,0.00001925561,0.0003755861],"genre_scores_gemma":[0.997972,0.0003863694,0.0006393311,0.00002400881,0.000004140262,0.00001189573,0.0002273132,0.000005996133,0.0007289403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004440259,"threshold_uncertainty_score":0.008828819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03296539407167051,"score_gpt":0.2968005479976797,"score_spread":0.2638351539260092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}