{"id":"W4405802352","doi":"10.1186/s12935-024-03611-y","title":"Protein kinase CK2 sustains de novo fatty acid synthesis by regulating the expression of SCD-1 in human renal cancer cells","year":2024,"lang":"en","type":"article","venue":"Cancer Cell International","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Novo Nordisk Fonden; Novo Nordisk","keywords":"Cancer; Cancer research; Kinase; Biochemistry; Fatty acid synthesis; Medicine; Cell biology; Biology; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001886297,0.000136371,0.0001224953,0.00004342505,0.00005534463,0.00003734709,0.0002867335,0.0001018563,0.0003953786],"category_scores_gemma":[0.0000258621,0.0001102574,0.00009329336,0.00007352653,0.00008501772,0.00001182486,0.000101544,0.000124259,7.874884e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000179763,"about_ca_system_score_gemma":0.0002500715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009221501,"about_ca_topic_score_gemma":0.0007121479,"domain_scores_codex":[0.9989901,0.00005449861,0.0002453789,0.0003106855,0.0001906295,0.0002086841],"domain_scores_gemma":[0.9995687,0.00001686747,0.00009173543,0.0001885614,0.00008763905,0.00004650377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005686147,0.00003660085,0.0002837618,0.00007153607,0.00002838803,4.676742e-7,0.0002005203,0.0005263556,0.9747717,0.0001045246,0.02155638,0.002362896],"study_design_scores_gemma":[0.0002271777,0.00001456176,0.0001274967,0.0002135455,0.00001402093,0.000001009667,0.0001211864,0.000207608,0.8556341,0.00003799641,0.1432897,0.000111598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799553,0.01299721,0.001386249,0.0004492745,0.002583926,0.0002948784,0.0003349663,0.00001440419,0.00198386],"genre_scores_gemma":[0.9916155,0.0008341405,0.0001842772,0.0001068704,0.003987733,0.0003558346,0.00004382645,0.00002666786,0.002845199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1217333,"threshold_uncertainty_score":0.4496164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008552008907055939,"score_gpt":0.2732304071683914,"score_spread":0.2646783982613354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}