{"id":"W4405813241","doi":"10.1093/cid/ciae622","title":"Immunogenicity, Reactogenicity, and Safety of a Pentavalent Meningococcal ABCWY Vaccine in Adolescents and Young Adults Who Had Previously Received a Meningococcal ACWY Vaccine: A Phase 3, Randomized Controlled Clinical Study","year":2024,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Moderna; Novavax; Shionogi; Sanofi; GlaxoSmithKline; Seqirus; AstraZeneca; Pfizer","keywords":"Reactogenicity; Medicine; Meningococcal vaccine; Immunogenicity; Vaccination; Meningococcal disease; Neisseria meningitidis; Confidence interval; Titer; Randomized controlled trial; Pediatrics; Immunology; Internal medicine; Antigen; Immunization; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003142784,0.001050496,0.002109784,0.0003052497,0.0004878136,0.0007246935,0.0006625181,0.001639509,0.002475795],"category_scores_gemma":[0.002280769,0.0006741677,0.001762147,0.0002815419,0.001105198,0.0006215981,0.0002977764,0.002371073,0.0003904933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006250094,"about_ca_system_score_gemma":0.001609883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008341693,"about_ca_topic_score_gemma":0.001310243,"domain_scores_codex":[0.9989139,0.0005968274,0.00009361811,0.0001394722,0.0001219417,0.0001343512],"domain_scores_gemma":[0.9979866,0.0005357706,0.0005497915,0.0001254949,0.000161041,0.0006413034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9381931,0.0336214,0.006638553,0.000504061,0.0008719811,0.00007831303,0.0001393342,0.0002871908,0.00537367,0.00005158632,0.000333682,0.01390715],"study_design_scores_gemma":[0.5533042,0.4332815,0.01130311,0.00003697675,0.0004172711,0.0000558954,0.00004352935,0.0003131642,0.0008227496,0.00005676166,0.0003543587,0.00001055609],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968231,0.0005630529,0.0001854126,0.00009640231,0.00006783863,0.001874047,0.0001786391,0.0000140366,0.0001975442],"genre_scores_gemma":[0.9929168,0.000721159,0.0007908714,0.0004011599,0.0001578221,0.004228021,0.0003200965,0.000006168897,0.0004579251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003142784,"threshold_uncertainty_score":0.01662087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01747451810620964,"score_gpt":0.348864920540674,"score_spread":0.3313904024344643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}