{"id":"W4405828632","doi":"10.17615/wkay-d758","title":"A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids","year":2024,"lang":"en","type":"article","venue":"UNC Libraries","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; Fogarty International Center; Great Southern Development Commission, Government of Western Australia; National Human Genome Research Institute; Helmholtz Zentrum München; National Key Research and Development Program of China; European Regional Development Fund; Cambridge Institute for Medical Research, University of Cambridge; Economic and Social Research Council; Samsung; National Institutes of Health; Korea Research Environment Open Network; Avera Institute for Human Genetics; National Institute on Aging; Universität Greifswald; MRC-PHE Centre for Environment and Health; Instituto de Salud Carlos III; National Institute for Nutrition and Health; Norwegian Biodiversity Information Centre; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Ministry of Science and ICT, South Korea; Institut de Cardiologie de Montréal; Imperial College London; King's College London; Fondation Institut de Cardiologie de Montréal; Taichung Veterans General Hospital; Forsknings- og Innovationsstyrelsen; Medical Research Council Canada; Wetenschappelijk Onderzoek- en Documentatiecentrum; Radboud Universitair Medisch Centrum; Office of Research and Development; Sydäntutkimussäätiö; Leids Universitair Medisch Centrum; Astellas Pharma; Instituto Mexicano del Seguro Social; Novo Nordisk; National Institute for Health Research Health Protection Research Unit; Vetenskapsrådet; Korea National Institute of Health; Oesterreichische Nationalbank; Ministry of Education, Culture, Sports, Science and Technology; Government of Western Australia; Karolinska Institutet; Medical Research Council; Hjärt-Lungfonden; Helsefonden; Korea Institute of Science and Technology Information; Korea Institute of Science and Technology; Accare; Finska Läkaresällskapet; Erasmus Medisch Centrum; National Medical Research Council; KfH-Stiftung Präventivmedizin; Stockholms Läns Landsting; National Science Council; National Research Foundation of Korea; Koninklijke Nederlandse Akademie van Wetenschappen; National Natural Science Foundation of China; Foundation for Cardiovascular Research; ZonMw; NIH Office of the Director; University of Notre Dame Australia; Edith Cowan University; Stiftelsen för Strategisk Forskning; Compute Canada; Radboud Universiteit; National Heart, Lung, and Blood Institute; Universiteit Leiden; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Chinese Academy of Sciences; Sundhed og Sygdom, Det Frie Forskningsråd; Murdoch University; China-Japan Friendship Hospital; Deutsche Forschungsgemeinschaft; Fondation Leducq; Hallym University; Austrian Science Fund; National Institute for Health and Care Research; National Research Foundation; National Center for Advancing Translational Sciences; European Science Foundation; Bundesministerium für Bildung und Forschung; Ministero dell’Istruzione, dell’Università e della Ricerca; British Heart Foundation; Women and Infants Research Foundation; Curtin University of Technology; Japan Agency for Medical Research and Development; Raine Medical Research Foundation; Daiwa Securities Health Foundation; University of Bristol; Canadian Institutes of Health Research; European Commission; Knut och Alice Wallenbergs Stiftelse; NIHR Cambridge Biomedical Research Centre; Scottish Funding Council; Novo Nordisk Foundation Center for Basic Metabolic Research; University of Notre Dame; Health and Safety Executive; National Health and Medical Research Council; Deutsche Krebshilfe; University of Oxford; AstraZeneca; U.S. Department of Veterans Affairs; Region Hovedstaden; Department for the Economy; Scottish Government; Broad Institute; Australian Government; Imperial College Healthcare NHS Trust; Perelman School of Medicine, University of Pennsylvania; Cancer Research UK; Wellcome Trust; EU Joint Programme – Neurodegenerative Disease Research; National Institute of Child Health and Human Development; Jan Dekker Stichting; Hjerteforeningen; Helsinki Institute of Life Science, Helsingin Yliopisto; Juvenile Diabetes Research Foundation International; National Institute of Allergy and Infectious Diseases; Danish Agency for Science and Higher Education; GlaxoSmithKline; Genome Canada; Gratama Stichting; Universität Regensburg; School of Medicine, Boston University; Helsingin Yliopisto; Public Health Agency; Center of Innovation Program; University of Pennsylvania; U.S. Department of Health and Human Services; American Diabetes Association; American Heart Association; Science Foundation Ireland; National Science Foundation; Andrea and Charles Bronfman Philanthropies; Diabetes UK","keywords":"Variation (astronomy); Layer (electronics); Computational biology; Biology; Genetics; Evolutionary biology; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001315317,0.000121517,0.000125831,0.0002362903,0.00005721093,0.0001694173,0.00009962454,0.0001148825,0.0001770091],"category_scores_gemma":[0.00003930798,0.0001152047,0.00009496932,0.000407364,0.00002042723,0.0000136596,0.00007591864,0.00005069795,0.0000377258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002735125,"about_ca_system_score_gemma":0.0001073965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002560162,"about_ca_topic_score_gemma":0.00008143537,"domain_scores_codex":[0.9991461,0.00005325725,0.0001772412,0.0003533647,0.0001003985,0.0001696096],"domain_scores_gemma":[0.999688,0.00002750204,0.00002168156,0.0001887293,0.00001557548,0.00005846563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006490051,0.00002267383,0.0009042757,0.00001885058,0.0003083681,0.00000605174,0.0005033599,0.002402465,0.9863319,0.007639105,0.0003848702,0.001413113],"study_design_scores_gemma":[0.001408357,0.0006131426,0.1741842,0.000122981,0.0008473431,0.0000194552,0.0009752222,0.02536878,0.718647,0.04890659,0.0273722,0.001534703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4243916,0.00179093,0.5723475,0.0004584767,0.0003372278,0.00018388,0.00001823403,0.00003351429,0.0004386003],"genre_scores_gemma":[0.9434524,0.00002578484,0.0545289,0.000261119,0.0002957344,0.00002549533,0.00004671948,0.00002205023,0.00134186],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5190607,"threshold_uncertainty_score":0.4697911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02982132794439703,"score_gpt":0.2415552167833227,"score_spread":0.2117338888389257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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