{"id":"W4405828632","doi":"10.17615/wkay-d758","title":"A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids","year":2024,"lang":"en","type":"article","venue":"UNC Libraries","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; Fogarty International Center; Great Southern Development Commission, Government of Western Australia; National Human Genome Research Institute; Helmholtz Zentrum München; National Key Research and Development Program of China; European Regional Development Fund; Cambridge Institute for Medical Research, University of Cambridge; Economic and Social Research Council; Samsung; National Institutes of Health; Korea Research Environment Open Network; Avera Institute for Human Genetics; National Institute on Aging; Universität Greifswald; MRC-PHE Centre for Environment and Health; Instituto de Salud Carlos III; National Institute for Nutrition and Health; Norwegian Biodiversity Information Centre; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Ministry of Science and ICT, South Korea; Institut de Cardiologie de Montréal; Imperial College London; King's College London; Fondation Institut de Cardiologie de Montréal; Taichung Veterans General Hospital; Forsknings- og Innovationsstyrelsen; Medical Research Council Canada; Wetenschappelijk Onderzoek- en Documentatiecentrum; Radboud Universitair Medisch Centrum; Office of Research and Development; Sydäntutkimussäätiö; Leids Universitair Medisch Centrum; Astellas Pharma; Instituto Mexicano del Seguro Social; Novo Nordisk; National Institute for Health Research Health Protection Research Unit; Vetenskapsrådet; Korea National Institute of Health; Oesterreichische Nationalbank; Ministry of Education, Culture, Sports, Science and Technology; Government of Western Australia; Karolinska Institutet; Medical Research Council; Hjärt-Lungfonden; Helsefonden; Korea Institute of Science and Technology Information; Korea Institute of Science and Technology; Accare; Finska Läkaresällskapet; Erasmus Medisch Centrum; National Medical Research Council; KfH-Stiftung Präventivmedizin; Stockholms Läns Landsting; National Science Council; National Research Foundation of Korea; Koninklijke Nederlandse Akademie van Wetenschappen; National Natural Science Foundation of China; Foundation for Cardiovascular Research; ZonMw; NIH Office of the Director; University of Notre Dame Australia; Edith Cowan University; Stiftelsen för Strategisk Forskning; Compute Canada; Radboud Universiteit; National Heart, Lung, and Blood Institute; Universiteit Leiden; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Chinese Academy of Sciences; Sundhed og Sygdom, Det Frie Forskningsråd; Murdoch University; China-Japan Friendship Hospital; Deutsche Forschungsgemeinschaft; Fondation Leducq; Hallym University; Austrian Science Fund; National Institute for Health and Care Research; National Research Foundation; National Center for Advancing Translational Sciences; European Science Foundation; Bundesministerium für Bildung und Forschung; Ministero dell’Istruzione, dell’Università e della Ricerca; British Heart Foundation; Women and Infants Research Foundation; Curtin University of Technology; Japan Agency for Medical Research and Development; Raine Medical Research Foundation; Daiwa Securities Health Foundation; University of Bristol; Canadian Institutes of Health Research; European Commission; Knut och Alice Wallenbergs Stiftelse; NIHR Cambridge Biomedical Research Centre; Scottish Funding Council; Novo Nordisk Foundation Center for Basic Metabolic Research; University of Notre Dame; Health and Safety Executive; National Health and Medical Research Council; Deutsche Krebshilfe; University of Oxford; AstraZeneca; U.S. Department of Veterans Affairs; Region Hovedstaden; Department for the Economy; Scottish Government; Broad Institute; Australian Government; Imperial College Healthcare NHS Trust; Perelman School of Medicine, University of Pennsylvania; Cancer Research UK; Wellcome Trust; EU Joint Programme – Neurodegenerative Disease Research; National Institute of Child Health and Human Development; Jan Dekker Stichting; Hjerteforeningen; Helsinki Institute of Life Science, Helsingin Yliopisto; Juvenile Diabetes Research Foundation International; National Institute of Allergy and Infectious Diseases; Danish Agency for Science and Higher Education; GlaxoSmithKline; Genome Canada; Gratama Stichting; Universität Regensburg; School of Medicine, Boston University; Helsingin Yliopisto; Public Health Agency; Center of Innovation Program; University of Pennsylvania; U.S. Department of Health and Human Services; American Diabetes Association; American Heart Association; Science Foundation Ireland; National Science Foundation; Andrea and Charles Bronfman Philanthropies; Diabetes UK","keywords":"Variation (astronomy); Layer (electronics); Computational biology; Biology; Genetics; Evolutionary biology; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002688984,0.0004412508,0.000372055,0.0008198996,0.0003670841,0.000605552,0.0003179323,0.0003660744,0.001710695],"category_scores_gemma":[0.0003362891,0.0002410778,0.0006540677,0.0005746703,0.0003822533,0.0005799416,0.0006002912,0.0008534974,0.0004349648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005733034,"about_ca_system_score_gemma":0.0003777917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001715042,"about_ca_topic_score_gemma":0.002529102,"domain_scores_codex":[0.9998583,0.00001941988,0.00001047232,0.00005051344,0.00003165937,0.00002955744],"domain_scores_gemma":[0.9997397,0.0001254837,0.00004487746,0.00004192809,0.00001990696,0.00002798831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000884465,0.00001322894,0.0006532376,0.00004058484,0.00001059583,0.00004427851,0.0000251948,0.0007056525,0.993052,0.0008740035,0.00002726336,0.004465478],"study_design_scores_gemma":[0.00001672933,0.0001400341,0.02608533,0.00001590945,0.0001014299,0.0003360766,0.0001238912,0.01407817,0.9519982,0.003254045,0.003811513,0.00003870673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8732715,0.0008265526,0.118081,0.0002691215,0.00002907011,0.00007060934,0.0030856,0.0008565339,0.003510119],"genre_scores_gemma":[0.9398999,0.0005565825,0.05326099,0.0001863131,0.00001401658,0.0000568368,0.002472121,0.0002061967,0.003347052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001715042,"threshold_uncertainty_score":0.005722821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02982132794439703,"score_gpt":0.2415552167833227,"score_spread":0.2117338888389257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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