{"id":"W4405842373","doi":"10.1101/2024.12.27.630504","title":"Combinations of genomic alterations and immune microenvironmental features associate with patient survival in multiple cancer types","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Immune system; Cancer; Computational biology; Biology; Medicine; Cancer research; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007434467,0.0002516725,0.0003976185,0.001067218,0.000225006,0.0006887708,0.00019043,0.0002572795,0.001553476],"category_scores_gemma":[0.001208294,0.00010439,0.0004610975,0.001192976,0.0002434957,0.0002171621,0.0005775383,0.0003768239,0.000177312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002051528,"about_ca_system_score_gemma":0.0001879922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008706598,"about_ca_topic_score_gemma":0.001246826,"domain_scores_codex":[0.9995263,0.0001105384,0.00004494754,0.0001433561,0.00009965412,0.00007533487],"domain_scores_gemma":[0.9991896,0.0002372392,0.0003162283,0.00009707481,0.00006462255,0.00009520438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003370819,0.00002668948,0.9742639,0.00002870787,0.0003098068,0.0001113623,0.00005067285,0.0005475028,0.01633274,0.00007710772,0.0002304032,0.007684075],"study_design_scores_gemma":[0.000005604867,0.0000721919,0.9931645,0.000005783921,0.0001646653,0.0003586711,0.00009184216,0.001580797,0.003693364,0.0002279068,0.0006282993,0.000006241677],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963837,0.0005856439,0.001332314,0.00008212152,0.000006553798,0.000005503111,0.001195429,0.0000329103,0.0003759274],"genre_scores_gemma":[0.9982966,0.00008429193,0.0006737922,0.00002385164,0.000007098298,0.00000540778,0.0007414458,0.000006866037,0.0001606703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001553476,"threshold_uncertainty_score":0.005196869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008909773209531995,"score_gpt":0.2172287816646204,"score_spread":0.2083190084550884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}