{"id":"W4405850907","doi":"10.1101/2024.12.23.629453","title":"Characterizing postoperative T and B cell dysfunction in cancer surgery patients, using COVID-19 as a model antigen","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Immune system; CD8; Antigen; Medicine; Disease; Surgical stress; T cell; Antibody; Immunology; Cell; Cancer; Cytotoxic T cell; Coronavirus disease 2019 (COVID-19); B cell; Internal medicine; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001588213,0.000218094,0.0001619428,0.0002069921,0.0001247531,0.0001843049,0.0001021039,0.0002773569,0.00200422],"category_scores_gemma":[0.0001280176,0.00006645486,0.0001533283,0.0001598695,0.0001421327,0.000129456,0.0001489312,0.0005149834,0.0003818549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009942844,"about_ca_system_score_gemma":0.00008096972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001588783,"about_ca_topic_score_gemma":0.0001095273,"domain_scores_codex":[0.9999151,0.00001799621,0.000008323597,0.00001804125,0.00001594017,0.00002445994],"domain_scores_gemma":[0.9999189,0.00001163141,0.00001917237,0.00001207202,0.00001170392,0.00002649142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001511226,0.0003202348,0.01726641,0.00005695238,0.00001774058,0.0001462654,0.0000532043,0.0001290393,0.9744153,0.00007365695,0.0002353828,0.005774472],"study_design_scores_gemma":[0.0002000564,0.01359498,0.2224685,0.00001603659,0.0001246735,0.002732055,0.0004771609,0.002998883,0.7511418,0.0003158123,0.005912857,0.00001724564],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981553,0.000260489,0.0007807225,0.00005397229,0.0000236834,0.0000238585,0.0002458424,0.00001384522,0.0004423182],"genre_scores_gemma":[0.9974953,0.0001777844,0.0007211394,0.00009507252,0.00001480801,0.00003516878,0.0004956087,0.000007986329,0.0009571652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00200422,"threshold_uncertainty_score":0.006704748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03100196050033171,"score_gpt":0.2722686730726874,"score_spread":0.2412667125723557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}