{"id":"W4405860248","doi":"10.1021/acs.est.4c11256","title":"Absence of a Causal Link between Elemental Carbon Exposure and Short-Term Respiratory Toxicity in Human-Derived Organoids and Cellular Models","year":2024,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Air Quality and Health Impacts","field":"Environmental Science","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada","funders":"National Natural Science Foundation of China","keywords":"Toxicity; Environmental chemistry; Potency; Chemistry; Particulates; Bioassay; Inhalation exposure; Respiratory system; Inhalation; Toxicology; Acute toxicity; Pharmacology; Biology; In vitro; Biochemistry; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001062158,0.0005047811,0.0004911119,0.000501175,0.0002652113,0.0008713208,0.0003833124,0.0007808443,0.001614209],"category_scores_gemma":[0.0009628619,0.0002613597,0.000539053,0.0004057194,0.0005748746,0.0005100843,0.0006527213,0.0009568152,0.0003948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004264865,"about_ca_system_score_gemma":0.0005664342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002166184,"about_ca_topic_score_gemma":0.004301117,"domain_scores_codex":[0.99907,0.0002814564,0.000100166,0.0002428408,0.0002424573,0.00006307085],"domain_scores_gemma":[0.9985119,0.0005063235,0.0003245583,0.000359919,0.0001882491,0.0001089265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002119845,0.0007581129,0.07129574,0.001022737,0.000580353,0.001252008,0.0002792111,0.001481779,0.905975,0.0008004191,0.0006598906,0.0137748],"study_design_scores_gemma":[0.00008878435,0.01025584,0.2668117,0.0001768197,0.001020293,0.004525567,0.001155871,0.006061823,0.6905038,0.002370686,0.01693593,0.00009282956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683089,0.01117361,0.01382126,0.0005399183,0.0001693394,0.0001905038,0.002363148,0.0001164504,0.003316921],"genre_scores_gemma":[0.9911535,0.003165236,0.002133864,0.0002072055,0.00002262639,0.0001346806,0.001377065,0.00001244961,0.001793317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002166184,"threshold_uncertainty_score":0.005617261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02774181795362778,"score_gpt":0.2817796983007606,"score_spread":0.2540378803471328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}