{"id":"W4405877673","doi":"10.1038/s41392-024-02076-9","title":"Malate initiates a proton-sensing pathway essential for pH regulation of inflammation","year":2024,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Neurological Disorders and Stroke; Army Medical University; Centre Scientifique et Technique du Bâtiment; National Institutes of Health; York University; Southwest Hospital; Fudan University; School of Pharmacy, Fudan University; National Natural Science Foundation of China; Chongqing Medical University; Wuhan University; NYU Langone Medical Center","keywords":"Cytosol; Biochemistry; Malate dehydrogenase; Chemistry; Signal transduction; Inflammation; Metabolite; In vitro; Downregulation and upregulation; Cell biology; Biology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002604118,0.0006779352,0.0004680224,0.0003085383,0.0003537929,0.0006246182,0.0003066398,0.0008205805,0.002262935],"category_scores_gemma":[0.0002134013,0.0002726709,0.000640704,0.0001986269,0.0003847496,0.0007893735,0.0006996752,0.0007964077,0.0009961292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005908557,"about_ca_system_score_gemma":0.0003545857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000333535,"about_ca_topic_score_gemma":0.0005143512,"domain_scores_codex":[0.9996483,0.00006392222,0.00002441319,0.00008898112,0.00007900209,0.00009534425],"domain_scores_gemma":[0.9998318,0.00001383397,0.00005301423,0.00001434673,0.00003650042,0.00005044961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000398135,0.00001822039,0.0004468521,0.0001466409,0.000008519306,0.0001409603,0.00001737438,0.00005277506,0.9972384,0.0003196943,0.0001218759,0.001090493],"study_design_scores_gemma":[0.00003231286,0.0002857279,0.006471345,0.00001697439,0.00001535011,0.0004722918,0.00007519881,0.0008164086,0.9841591,0.0004362589,0.007201885,0.00001729983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9110988,0.02571519,0.04547887,0.002554906,0.0004862444,0.0002744377,0.004222207,0.001028714,0.009140639],"genre_scores_gemma":[0.9841059,0.003656213,0.007045556,0.0005057215,0.00006910261,0.00007815311,0.001347053,0.00004458605,0.003147821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002262935,"threshold_uncertainty_score":0.007570207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01253303796872893,"score_gpt":0.2486844915583173,"score_spread":0.2361514535895884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}