{"id":"W4405884245","doi":"10.1016/j.parkreldis.2024.107257","title":"A Phase 2b, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of intravenous prasinezumab in early-stage Parkinson's disease (PADOVA): Rationale, design, and baseline data","year":2024,"lang":"en","type":"article","venue":"Parkinsonism & Related Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"F. Hoffmann-La Roche","keywords":"Placebo; Medicine; Parkinson's disease; Stage (stratigraphy); Double blind; Phases of clinical research; Disease; Internal medicine; Clinical trial; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003796749,0.002831852,0.002787492,0.0005700423,0.000728278,0.001087931,0.0008761549,0.002128415,0.005186624],"category_scores_gemma":[0.002398761,0.001187922,0.001352345,0.0005324889,0.00153897,0.001164115,0.0004465752,0.002554743,0.001127699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005188477,"about_ca_system_score_gemma":0.002351584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003249615,"about_ca_topic_score_gemma":0.0009625707,"domain_scores_codex":[0.9988163,0.0006205263,0.00008250923,0.0002339139,0.0001140518,0.0001327965],"domain_scores_gemma":[0.9989195,0.000246233,0.0002701708,0.0001021972,0.0001328431,0.0003290069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.948876,0.02502227,0.001526359,0.0008976663,0.0007648034,0.00007024786,0.00008505343,0.0003095747,0.007642639,0.0002036914,0.001200709,0.01340106],"study_design_scores_gemma":[0.9208558,0.07531518,0.001933419,0.00002397243,0.0002541182,0.00003588615,0.00000986953,0.0001919114,0.0004970774,0.00009438112,0.0007765575,0.00001176532],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9475783,0.005630251,0.002977396,0.0008458488,0.0007168616,0.03588768,0.003141223,0.0002631599,0.002959369],"genre_scores_gemma":[0.934522,0.002445485,0.008064304,0.001941267,0.0006975606,0.04619707,0.002760361,0.00005548043,0.003316397],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.005186624,"threshold_uncertainty_score":0.02007931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03221762873411688,"score_gpt":0.3260528513581589,"score_spread":0.293835222624042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}