{"id":"W4405894693","doi":"10.1016/j.celrep.2024.115138","title":"mRNA decay pre-complex assembly drives timely cell-state transitions during differentiation","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research","keywords":"Cell biology; Messenger RNA; Cellular differentiation; State (computer science); Chemistry; Biology; Computational biology; Computer science; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137074,0.0001714435,0.0001724168,0.0001056748,0.0001624102,0.0004260091,0.0001502973,0.0001367953,0.001016217],"category_scores_gemma":[0.0001687995,0.000166029,0.0001179086,0.00007159016,0.000170185,0.0001831213,0.0002613126,0.0003426952,0.0004428213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005120299,"about_ca_system_score_gemma":0.0002288241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006191815,"about_ca_topic_score_gemma":0.001640884,"domain_scores_codex":[0.9998926,0.000008691321,0.000008709418,0.00002971296,0.00003761013,0.00002258243],"domain_scores_gemma":[0.9998689,0.00001740732,0.00002926208,0.00001800734,0.00002411559,0.00004225151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003267391,0.000003347609,0.0002127458,0.000009054764,0.000001008272,0.00002420254,0.000009225985,0.0000387519,0.9986689,0.0001933453,0.00002440244,0.000782514],"study_design_scores_gemma":[0.000005509374,0.00003844647,0.008649553,0.000003036009,0.000003996403,0.0001002031,0.00001695093,0.001094268,0.9879642,0.00008670973,0.002034865,0.000002273792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870986,0.001115361,0.008579958,0.00006653688,0.00002625482,0.00001398873,0.0001797538,0.0001951233,0.002724453],"genre_scores_gemma":[0.9953867,0.0002190833,0.001367382,0.00001699871,0.000004671361,0.00000799902,0.0002132252,0.00002581069,0.002758165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001016217,"threshold_uncertainty_score":0.003715098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009312347663291936,"score_gpt":0.2554090065351878,"score_spread":0.2460966588718958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}