{"id":"W4405896280","doi":"10.1158/0008-5472.can-24-4907","title":"Switching Drivers: Epigenetic Rewiring to Genetic Progression in Glioma","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"","keywords":"Epigenetics; CDKN2A; Glioma; Cancer research; Biology; Tumor progression; PDGFRA; CDKN2B; Gene; Genetics; Stromal cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002001092,0.0002386912,0.0002110496,0.0003803447,0.000190369,0.0005831445,0.0002550023,0.000362816,0.001856036],"category_scores_gemma":[0.0002890622,0.0002305274,0.0002105967,0.0001879398,0.0004006025,0.0004734751,0.0004360194,0.0006965323,0.0003970477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006033867,"about_ca_system_score_gemma":0.0002884552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008194169,"about_ca_topic_score_gemma":0.001689728,"domain_scores_codex":[0.9998747,0.0000111627,0.000006698575,0.00003046102,0.00004431989,0.00003258881],"domain_scores_gemma":[0.9998735,0.00001849005,0.00004512158,0.00001722351,0.00001440068,0.00003116946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003025195,0.00005480091,0.004679389,0.0001217809,0.00003212777,0.0004304334,0.000190831,0.0009932466,0.9277739,0.007373516,0.001072128,0.05697535],"study_design_scores_gemma":[0.00006695177,0.0007920723,0.04528822,0.00005773557,0.0001248966,0.003408713,0.0004383213,0.009244791,0.8507504,0.01078785,0.07897051,0.00006942085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.953787,0.008915929,0.02102558,0.00152807,0.0001942567,0.00009432557,0.0004408947,0.001227713,0.01278629],"genre_scores_gemma":[0.9894712,0.003253478,0.002266319,0.000292596,0.00003663498,0.00001859503,0.0001666297,0.00006445934,0.004430177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001856036,"threshold_uncertainty_score":0.006209016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08285975771946295,"score_gpt":0.4691280991689585,"score_spread":0.3862683414494955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}