{"id":"W4405901833","doi":"10.1101/2024.12.30.630684","title":"Astrocyte-derived extracellular matrix proteins regulate synapse remodeling in stress-induced depression","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Extracellular matrix; Astrocyte; Synapse; Neuroscience; Depression (economics); Cell biology; Extracellular; Biology; Central nervous system; Economics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005493866,0.0001759132,0.0001375144,0.0001692735,0.0001260537,0.0001489741,0.00005206862,0.0001397873,0.0004505388],"category_scores_gemma":[0.00005395713,0.00008496096,0.0001778253,0.0001162554,0.00009947444,0.00005713423,0.0001171187,0.0002410631,0.0001188671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001630003,"about_ca_system_score_gemma":0.0000922929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007690651,"about_ca_topic_score_gemma":0.001486527,"domain_scores_codex":[0.9999576,0.000006058062,0.000003767726,0.000008295643,0.00001054735,0.00001377278],"domain_scores_gemma":[0.9999583,0.00000234136,0.00001552236,0.000002464693,0.000008907235,0.000012525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001618803,0.00001687581,0.001303939,0.00002859102,0.000009758296,0.00006276737,0.00001200027,0.0000329367,0.9975158,0.00002813128,0.00003879452,0.0007885055],"study_design_scores_gemma":[0.00005702105,0.0006176047,0.4067992,0.00003114417,0.00008782106,0.0007029496,0.000235752,0.002427239,0.5860386,0.0002641643,0.002726404,0.00001211866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962674,0.001542107,0.001071559,0.00006272111,0.00001793636,0.00001750481,0.0004125249,0.00002856908,0.0005796836],"genre_scores_gemma":[0.9973175,0.0008476077,0.0007096191,0.00005306571,0.000005501328,0.00002009144,0.0003306643,0.000004819702,0.00071114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007690651,"threshold_uncertainty_score":0.001529217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02079942892631356,"score_gpt":0.2439663209737858,"score_spread":0.2231668920474722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}