{"id":"W4405909880","doi":"10.1371/journal.pone.0316331","title":"Evidence for gene essentiality in Leishmania using CRISPR","year":2024,"lang":"en","type":"article","venue":"PLoS ONE","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"CRISPR; Leishmania; Biology; Gene; Genetics; Computational biology; Computer science; Parasite hosting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003961881,0.0003833581,0.0002834436,0.00056792,0.000240613,0.0004551204,0.0004772971,0.0007439885,0.003090929],"category_scores_gemma":[0.0005961123,0.0002643439,0.0004617137,0.0002394283,0.0006278366,0.0003707364,0.0005398464,0.00106658,0.0007014388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002876368,"about_ca_system_score_gemma":0.0002928972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005860645,"about_ca_topic_score_gemma":0.001113395,"domain_scores_codex":[0.9994125,0.00009014303,0.00007725696,0.0001328263,0.0002004981,0.00008684966],"domain_scores_gemma":[0.9992681,0.0002437612,0.0001373895,0.0001518033,0.0001030624,0.00009588068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007235315,0.00001268365,0.0003592171,0.0001303562,0.00001504943,0.0003264802,0.00003461347,0.0001070578,0.9956506,0.0009263191,0.0001973387,0.0021679],"study_design_scores_gemma":[0.00003112281,0.0003294567,0.006888627,0.00003890697,0.00007006375,0.003219962,0.0001257764,0.002010578,0.9685882,0.0007138202,0.01795607,0.00002730129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9223346,0.00398791,0.04917596,0.001620623,0.00027222,0.0001103991,0.002851956,0.001640625,0.01800582],"genre_scores_gemma":[0.9854608,0.001507081,0.008517746,0.000392479,0.00001774828,0.00005192834,0.001162844,0.0001457956,0.002743541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003090929,"threshold_uncertainty_score":0.01034015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1035336235388368,"score_gpt":0.362520938153302,"score_spread":0.2589873146144652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}