{"id":"W4405923527","doi":"10.1093/neuonc/noae276","title":"A hitchhiker’s guide to cerebrospinal fluid biomarkers for neuro-oncology","year":2024,"lang":"en","type":"review","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"School of Medicine, Duke University; National Institutes of Health; Center for Clinical and Translational Science, Mayo Clinic; University of California, Los Angeles; Universitätsklinikum Heidelberg; University of Pennsylvania; Deutschen Konsortium für Translationale Krebsforschung; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Massachusetts General Hospital; National Cancer Institute; Center for Individualized Medicine, Mayo Clinic; University of Toronto; Deutsches Krebsforschungszentrum; David Geffen School of Medicine, University of California, Los Angeles; Pennsylvania State University","keywords":"Medicine; Internal medicine; Oncology; Clinical Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0005807612,0.001385211,0.005472327,0.001258941,0.0001878067,0.00007747073,0.0006220931,0.001501496,0.0002874091],"category_scores_gemma":[0.001340568,0.001061027,0.002180083,0.001119675,0.0002140237,0.00005907259,0.0005466726,0.001014459,0.001961514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002562663,"about_ca_system_score_gemma":0.004172255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006338907,"about_ca_topic_score_gemma":0.00009078289,"domain_scores_codex":[0.9932979,0.0005584669,0.002023319,0.00223112,0.0004688416,0.001420319],"domain_scores_gemma":[0.9941956,0.002601428,0.0005850874,0.001292983,0.0002825151,0.001042331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002399984,0.0007467952,0.00000977298,0.006201179,0.0010105,0.003749307,0.00005005321,4.602082e-7,0.001418294,0.0002157855,0.4149204,0.5714375],"study_design_scores_gemma":[0.003086444,0.01206436,0.000006798065,0.002886606,0.01242696,0.004537931,0.00003278669,0.00001840497,0.000130012,0.00003985312,0.9641131,0.0006567293],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007074147,0.9661751,0.00005266855,0.0111052,0.006881763,0.008539818,0.0004623382,0.0003745044,0.006337821],"genre_scores_gemma":[0.00002437093,0.9787555,0.002549979,0.008417292,0.001938857,0.00694346,0.000502581,0.0004416124,0.0004263539],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5707808,"threshold_uncertainty_score":0.9998899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05875035359369118,"score_gpt":0.4047582591843036,"score_spread":0.3460079055906124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}