{"id":"W4405937755","doi":"10.3390/v17010054","title":"Exploiting the Achilles’ Heel of Viral RNA Processing to Develop Novel Antivirals","year":2024,"lang":"en","type":"article","venue":"Viruses","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Biology; Viral replication; RNA; Virology; Virus; Proteases; Influenza A virus; Viral entry; Gene; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007821748,0.0005190953,0.0007124338,0.0004002933,0.0003565805,0.001404757,0.0003600938,0.0007969198,0.002388803],"category_scores_gemma":[0.0003517503,0.0003519632,0.0004085694,0.0001921186,0.0009124572,0.002055702,0.0005245414,0.002126181,0.001170636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005059735,"about_ca_system_score_gemma":0.0006104881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002410666,"about_ca_topic_score_gemma":0.0005353944,"domain_scores_codex":[0.9997498,0.00004855645,0.00001761283,0.00004740216,0.00007471259,0.00006181776],"domain_scores_gemma":[0.9998472,0.0000571927,0.00002824273,0.00002329502,0.00001957242,0.00002452819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002756625,0.0001421817,0.0004404712,0.0006939459,0.00004618386,0.0002881601,0.0001506907,0.001602847,0.9067146,0.01939591,0.0007019846,0.06954745],"study_design_scores_gemma":[0.0001303834,0.003227032,0.001564514,0.0001938357,0.00007494092,0.001467154,0.0002165458,0.00556426,0.8550577,0.02200213,0.1104328,0.00006866807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5722598,0.2094747,0.1616736,0.01434973,0.001202981,0.0004142707,0.0006387508,0.0008419089,0.03914415],"genre_scores_gemma":[0.8251501,0.1068143,0.05029759,0.003293635,0.0005116805,0.000191499,0.0003197072,0.0001255447,0.01329595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002388803,"threshold_uncertainty_score":0.007991374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04973815572800886,"score_gpt":0.3472705111896577,"score_spread":0.2975323554616488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}