{"id":"W4405940844","doi":"10.3390/pharmaceutics17010042","title":"Liposomal Formulation of Hydroxychloroquine Can Inhibit Autophagy In Vivo","year":2024,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Simon Fraser University; BC Innovation Council; University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Uppsala Universitet; Mitacs","keywords":"Gefitinib; In vivo; Autophagy; Hydroxychloroquine; Pharmacology; Medicine; Liposome; Drug; Pharmacokinetics; Cancer; Cancer research; Chemistry; Internal medicine; Biology; Epidermal growth factor receptor; Biochemistry; Apoptosis; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001261815,0.0001225158,0.0002031403,0.0001976541,0.00001750729,0.00001026922,0.00005429009,0.00006694116,0.0005495376],"category_scores_gemma":[0.00001438657,0.0001115584,0.00008787737,0.0003439098,0.00003397601,0.00008469152,0.00002362665,0.000186642,0.00002074607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008206697,"about_ca_system_score_gemma":0.0001310741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002605293,"about_ca_topic_score_gemma":0.000008185219,"domain_scores_codex":[0.9990939,0.00001883758,0.0002969369,0.0001727638,0.0002154218,0.0002021122],"domain_scores_gemma":[0.9996215,0.00004641485,0.00003624286,0.0001500402,0.00003548455,0.0001103553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007973446,0.0008846123,0.0147544,0.001825807,0.0004386144,0.0009835309,0.003505592,0.000432443,0.9103168,0.009438822,0.001250158,0.05537188],"study_design_scores_gemma":[0.001865964,0.0001429228,0.003701577,0.0002682141,0.000161864,0.00004621821,0.00003225615,0.06472771,0.9087601,0.001105627,0.01905332,0.0001341996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915001,0.004259908,0.00008322667,0.0006636779,0.0003138065,0.0002938196,0.00003231598,0.0001096899,0.002743444],"genre_scores_gemma":[0.9979634,0.0004130641,0.0001205197,0.0005229207,0.0002042565,0.00001270401,0.00002025981,0.00002824904,0.0007146807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06429527,"threshold_uncertainty_score":0.6017051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03146398663385967,"score_gpt":0.356836516205137,"score_spread":0.3253725295712773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}