{"id":"W4405940844","doi":"10.3390/pharmaceutics17010042","title":"Liposomal Formulation of Hydroxychloroquine Can Inhibit Autophagy In Vivo","year":2024,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Simon Fraser University; BC Innovation Council; University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Uppsala Universitet; Mitacs","keywords":"Gefitinib; In vivo; Autophagy; Hydroxychloroquine; Pharmacology; Medicine; Liposome; Drug; Pharmacokinetics; Cancer; Cancer research; Chemistry; Internal medicine; Biology; Epidermal growth factor receptor; Biochemistry; Apoptosis; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002618154,0.0002232036,0.0001818521,0.0001513013,0.00009770534,0.0002501631,0.0001852252,0.0002875318,0.001259277],"category_scores_gemma":[0.0001862363,0.00008563069,0.000165648,0.00007961377,0.000256026,0.0002707682,0.0001641754,0.0003525517,0.0003012496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003280544,"about_ca_system_score_gemma":0.0002155836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004367229,"about_ca_topic_score_gemma":0.0004219522,"domain_scores_codex":[0.999892,0.00002415088,0.000009041452,0.00002481701,0.00002862266,0.00002141003],"domain_scores_gemma":[0.9998604,0.00002894984,0.00004622665,0.00001264464,0.00003221728,0.00001951933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002533532,0.0000747778,0.00008567947,0.00009503038,0.000009821922,0.00003603165,0.0000214845,0.000211261,0.9957591,0.0001318756,0.00009926177,0.003222355],"study_design_scores_gemma":[0.00007982213,0.001171424,0.0006309003,0.00001403109,0.00002527473,0.0001090726,0.00001180017,0.001269173,0.9932966,0.00003525747,0.003351407,0.000005385084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803619,0.004191332,0.01238703,0.0002695443,0.00007217492,0.0002028586,0.0001941385,0.0001548124,0.002166064],"genre_scores_gemma":[0.9928707,0.00115514,0.004183808,0.00007924677,0.00001803326,0.00008118688,0.0002155425,0.00002654492,0.001369852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001259277,"threshold_uncertainty_score":0.004212677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03146398663385967,"score_gpt":0.356836516205137,"score_spread":0.3253725295712773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}