{"id":"W4405943350","doi":"10.1021/acsami.4c20077","title":"Transfection Potency of Lipid Nanoparticles Containing mRNA Depends on Relative Loading Levels","year":2024,"lang":"en","type":"article","venue":"ACS Applied Materials & Interfaces","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Networks of Centres of Excellence of Canada; Canada Research Chairs; Michael Smith Health Research BC","keywords":"Potency; Materials science; Nanoparticle; Transfection; Messenger RNA; Nanotechnology; Biophysics; Biochemistry; In vitro; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002446264,0.0001858078,0.0002160024,0.00006058784,0.00006179637,0.00009415015,0.0001519678,0.0001424448,0.0001452196],"category_scores_gemma":[0.00001909176,0.0001617849,0.00003047707,0.00006405492,0.00006192741,0.00001458235,0.00005489245,0.00007518262,0.00005554514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001617781,"about_ca_system_score_gemma":0.00003036368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004085013,"about_ca_topic_score_gemma":0.00001271147,"domain_scores_codex":[0.9989359,0.00004361389,0.0003366581,0.0003624659,0.0001077191,0.0002136282],"domain_scores_gemma":[0.9996533,0.00002837376,0.00006989637,0.0001757386,0.0000428395,0.00002982361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003778362,0.00002727048,0.00000754081,0.00005864476,0.0001252629,0.000002590138,0.0003646663,0.00004289682,0.993736,0.0009954119,0.0001819917,0.004079855],"study_design_scores_gemma":[0.0002097026,0.0007390102,0.00006386959,0.0001604302,0.0000332789,0.000007460536,0.0002675999,0.000001621092,0.9975564,0.0005139749,0.0002731512,0.0001735118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951441,0.0003845257,0.0002346177,0.00005517829,0.0005644221,0.0001617567,0.00006822356,0.00003614978,0.003350982],"genre_scores_gemma":[0.9991439,0.0001293026,0.00006289261,0.00006227192,0.0001993,0.00003618905,0.0000272091,0.0000274034,0.0003115417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003999745,"threshold_uncertainty_score":0.6597395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01845149482753146,"score_gpt":0.2624424802512564,"score_spread":0.2439909854237249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}