{"id":"W4405944467","doi":"10.1128/aem.01971-24","title":"RecA deletion disrupts protein homeostasis, leading to deamidation, oxidation, and impaired glycolysis in <i>Cronobacter sakazakii</i>","year":2024,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Enterobacteriaceae and Cronobacter Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Deamidation; Cronobacter sakazakii; Glycolysis; Biology; Homeostasis; Microbiology; Chemistry; Biochemistry; Cell biology; Metabolism; Bacteria; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000128541,0.0001717827,0.0001519172,0.00009432429,0.00006753773,0.00006354992,0.00007770604,0.0001465733,0.00003804365],"category_scores_gemma":[0.000004275142,0.0001651168,0.00002754696,0.00007457771,0.000111675,0.00001195501,0.0001923497,0.00009061152,0.00004321525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004792226,"about_ca_system_score_gemma":0.00001267244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001732944,"about_ca_topic_score_gemma":0.00007021143,"domain_scores_codex":[0.9989148,0.00004681813,0.0002016512,0.0005246977,0.00003206758,0.0002799137],"domain_scores_gemma":[0.9997286,0.000008989756,0.00002459632,0.0001532854,0.00000310234,0.00008148491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008809339,0.00003554002,0.005320858,0.0000299727,0.00003156468,0.000003333071,0.0001206343,0.000002244039,0.981372,0.00003734574,0.0001969696,0.01276146],"study_design_scores_gemma":[0.0007635313,0.0003479843,0.03327472,0.00005782146,0.00002221665,0.00007932996,0.0003756479,0.000006745307,0.8991144,0.00006852834,0.06546449,0.0004245509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980285,0.0007720865,0.0003261271,0.0002610506,0.00003641606,0.0004404353,0.00006290329,0.00001291177,0.00005962908],"genre_scores_gemma":[0.997449,0.0005347321,0.0002694682,0.0002404405,0.00005999175,0.0001239872,0.001107795,0.00002304099,0.0001915586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08225756,"threshold_uncertainty_score":0.6733269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004149280983311735,"score_gpt":0.216196512630777,"score_spread":0.2120472316474652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}