{"id":"W4405948754","doi":"10.1101/2024.12.30.630787","title":"Donor Strand Complementation and Calcium Ion Coordination Drive the Chaperone-free Polymerization of Archaeal Cannulae","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"","keywords":"Complementation; Chemistry; Calcium; Chaperone (clinical); Ion; Biophysics; Cell biology; Biochemistry; Biology; Medicine; Phenotype; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001098541,0.0001749215,0.0001345434,0.00009987639,0.0001854419,0.0003076571,0.0001606403,0.0002433618,0.0004172122],"category_scores_gemma":[0.0002333062,0.0001959553,0.0001790416,0.00009065394,0.0002565677,0.0002167775,0.0002868913,0.0004449102,0.0002182745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001793586,"about_ca_system_score_gemma":0.000175271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00037767,"about_ca_topic_score_gemma":0.0003797598,"domain_scores_codex":[0.999931,0.00000851917,0.000003784673,0.00002202427,0.00001726181,0.00001742491],"domain_scores_gemma":[0.9998146,0.0000330138,0.00005071768,0.00002917517,0.00002886487,0.0000436959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002394833,0.000006074017,0.0003665743,0.00001252588,0.000001546566,0.00005604958,0.00002408946,0.00005990627,0.9989567,0.00007616849,0.00001405922,0.0004023329],"study_design_scores_gemma":[0.0000129389,0.0001027648,0.009037299,0.000005785225,0.000004845072,0.0002617844,0.00008744426,0.003048576,0.985594,0.0001189654,0.001716768,0.000009028335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976493,0.00009009941,0.001768428,0.00002111309,0.000005749144,0.000007701808,0.00003320415,0.00004520741,0.0003792387],"genre_scores_gemma":[0.9979665,0.00004008049,0.00148989,0.00001202645,0.000001636295,0.000006076149,0.00006529785,0.00001307039,0.0004054786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004172122,"threshold_uncertainty_score":0.001395702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01366606027311489,"score_gpt":0.2326118970067529,"score_spread":0.218945836733638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}