{"id":"W4405960718","doi":"10.1093/geroni/igae098.1872","title":"SINGLE-CELL ANALYSIS OF SOMATIC MUTATIONS IN HUMAN LUNG REVEALS ASSOCIATION WITH TRANSCRIPTIONAL CHANGES IN AGING","year":2024,"lang":"en","type":"article","venue":"Innovation in Aging","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Somatic cell; Biology; Genetics; Association (psychology); Cell; Computational biology; Cell biology; Gene; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004799144,0.0002000373,0.0004910579,0.0008241005,0.0002924995,0.0005509269,0.0002618188,0.0004087234,0.002101959],"category_scores_gemma":[0.0009195274,0.0001636737,0.0003748176,0.0007877335,0.0001698382,0.0001485096,0.0003912948,0.000368854,0.001180886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002337936,"about_ca_system_score_gemma":0.0001866154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001209031,"about_ca_topic_score_gemma":0.002084644,"domain_scores_codex":[0.9995496,0.00003403404,0.00003549309,0.0002066981,0.0001242189,0.0000499876],"domain_scores_gemma":[0.9994527,0.000161282,0.00009764621,0.00008031301,0.0001545736,0.00005350015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00108771,0.00008337206,0.2854773,0.0008625984,0.0004212471,0.0007225035,0.0002850445,0.001817214,0.6667788,0.0002716857,0.006148373,0.0360442],"study_design_scores_gemma":[0.00004735819,0.0003327135,0.8759639,0.00007841911,0.0002575812,0.003096652,0.0002123253,0.00637169,0.09787721,0.0007894651,0.01492051,0.00005216172],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9481826,0.004822021,0.006002126,0.0001391479,0.00004465385,0.00004014114,0.03941568,0.0003711676,0.0009823838],"genre_scores_gemma":[0.9371343,0.001130351,0.006362653,0.0002373846,0.0000344039,0.0001084845,0.05346955,0.0001159528,0.001406922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002101959,"threshold_uncertainty_score":0.007031739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01470995236547827,"score_gpt":0.2725482777479329,"score_spread":0.2578383253824546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}