{"id":"W4405965731","doi":"10.3390/vaccines13010033","title":"Transcriptional Systems Vaccinology Approaches for Vaccine Adjuvant Profiling","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University; University of Saskatchewan","funders":"","keywords":"Computational biology; Adjuvant; Immune system; Biology; Systems biology; Vaccine adjuvant; Innate immune system; Gene; Mechanism (biology); Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002966197,0.001005328,0.001636138,0.001351745,0.000601195,0.002486598,0.001209236,0.001403714,0.003511583],"category_scores_gemma":[0.002040714,0.0007460916,0.001511908,0.001110951,0.001040007,0.001730596,0.001533928,0.004491298,0.003042015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00130598,"about_ca_system_score_gemma":0.001081257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006180854,"about_ca_topic_score_gemma":0.001026744,"domain_scores_codex":[0.9982404,0.0004941621,0.0001058765,0.0004718688,0.0005438902,0.0001438151],"domain_scores_gemma":[0.9989142,0.000525392,0.0001222227,0.0001516885,0.0002309176,0.00005567535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001859968,0.0001213371,0.001749709,0.002438904,0.000147632,0.0001728919,0.0002685302,0.004623893,0.8606653,0.02293953,0.004910546,0.1017758],"study_design_scores_gemma":[0.00006658954,0.0006863946,0.003538273,0.0004793649,0.0002825568,0.0008532049,0.0003792637,0.03521262,0.5792583,0.03022362,0.3488241,0.0001957167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.02693051,0.05090641,0.9002568,0.003400134,0.001413131,0.0008122203,0.003623727,0.00379234,0.008864677],"genre_scores_gemma":[0.1350877,0.07036961,0.7701653,0.003552018,0.001101392,0.002041515,0.007507189,0.00146305,0.008712208],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003511583,"threshold_uncertainty_score":0.01568693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02967845603781282,"score_gpt":0.249279681844984,"score_spread":0.2196012258071712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}