{"id":"W4405965731","doi":"10.3390/vaccines13010033","title":"Transcriptional Systems Vaccinology Approaches for Vaccine Adjuvant Profiling","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University; University of Saskatchewan","funders":"","keywords":"Computational biology; Adjuvant; Immune system; Biology; Systems biology; Vaccine adjuvant; Innate immune system; Gene; Mechanism (biology); Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003177712,0.0001900342,0.0003571704,0.0002777348,0.0002312858,0.00002182799,0.0002030053,0.000278915,0.00006480006],"category_scores_gemma":[0.0001076352,0.0001581953,0.0001254018,0.0001782178,0.00001246304,0.0001268196,0.00003162434,0.0001480355,0.00008860654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000034149,"about_ca_system_score_gemma":0.00008966509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002010359,"about_ca_topic_score_gemma":0.000008977002,"domain_scores_codex":[0.99876,0.0001360663,0.0004471611,0.000300572,0.00002028893,0.0003359167],"domain_scores_gemma":[0.9993105,0.0002094817,0.00009982752,0.0002478623,0.0001226284,0.000009722601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003682497,0.0002190567,0.004716845,0.0005172781,0.0007900971,0.000001680998,0.0002903685,0.000430311,0.7541127,0.1938588,0.0144535,0.02692683],"study_design_scores_gemma":[0.0105486,0.0004639764,0.04770484,0.0002082078,0.0003595578,0.0001180801,0.001613183,0.002116201,0.5893933,0.002675761,0.3441537,0.0006445149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9066162,0.05122933,0.02818505,0.003376593,0.005411735,0.002221444,0.00004926287,0.0003621464,0.00254832],"genre_scores_gemma":[0.9886722,0.0001205237,0.0002083429,0.00009514884,0.00009436573,0.0004057122,0.0004088516,0.0000163935,0.009978482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3297002,"threshold_uncertainty_score":0.6451017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02967845603781282,"score_gpt":0.249279681844984,"score_spread":0.2196012258071712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}