{"id":"W4405967508","doi":"10.1126/scitranslmed.adi6148","title":"G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells","year":2025,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; University of Pennsylvania","keywords":"Glucokinase; Internal medicine; Endocrinology; Biology; Glucagon; Insulin; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001176011,0.000371471,0.0002000835,0.0002732831,0.000153589,0.0004424093,0.0002625631,0.0002587013,0.001093569],"category_scores_gemma":[0.0001749719,0.0001824614,0.0002083927,0.0001664768,0.0004759503,0.0001701941,0.0002778002,0.0005034445,0.0003097736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002928483,"about_ca_system_score_gemma":0.000196824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005057013,"about_ca_topic_score_gemma":0.000810602,"domain_scores_codex":[0.9998704,0.00002396836,0.00001036467,0.0000439876,0.00002601629,0.00002521201],"domain_scores_gemma":[0.9998379,0.00002101167,0.0000473452,0.00002359616,0.00001030344,0.00005988625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002004516,0.00001054964,0.0002939838,0.000007115314,0.000001943957,0.00002785708,0.00001135814,0.000040319,0.9988152,0.0001051353,0.00001672361,0.000469345],"study_design_scores_gemma":[0.00008299103,0.0002517267,0.01243658,0.000007608778,0.000018642,0.0002806796,0.00005123291,0.001263397,0.9822543,0.0001743946,0.00316977,0.000008662937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942182,0.0005630287,0.0036345,0.0001003244,0.00005440291,0.00001979517,0.0002232044,0.00009480175,0.001091743],"genre_scores_gemma":[0.9955616,0.0003901098,0.001975301,0.00008730173,0.00001694876,0.00002765508,0.000284756,0.00006169519,0.001594582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001093569,"threshold_uncertainty_score":0.003658354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01513284837096205,"score_gpt":0.2969363621993645,"score_spread":0.2818035138284024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}