{"id":"W4405971653","doi":"10.1038/s41422-024-01030-2","title":"LKB1 inactivation unleashes prostate cancer lineage plasticity","year":2025,"lang":"en","type":"article","venue":"Cell Research","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Government of Canada; Prostate Cancer Foundation","keywords":"Biology; Lineage (genetic); Prostate cancer; Genetics; Cancer; Evolutionary biology; Cancer research; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001817069,0.0002394963,0.0002223178,0.000579274,0.0003280431,0.0009186762,0.0003540107,0.0004435134,0.004923842],"category_scores_gemma":[0.0003857888,0.0003289036,0.0002485728,0.0002810388,0.0004462743,0.0003322737,0.0006698882,0.001134732,0.00114829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004400663,"about_ca_system_score_gemma":0.0006478173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001277152,"about_ca_topic_score_gemma":0.003638945,"domain_scores_codex":[0.9997888,0.00003001051,0.00001643073,0.00003734377,0.00004955414,0.00007778843],"domain_scores_gemma":[0.9996674,0.00006716622,0.00006947545,0.00005795548,0.00002197444,0.0001160541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005174902,0.00004692898,0.003429923,0.00009225476,0.00002429109,0.0005340141,0.00008711994,0.0002720667,0.9812625,0.003592985,0.001195942,0.008944419],"study_design_scores_gemma":[0.00009995881,0.0004313629,0.03786468,0.00003966475,0.00007702679,0.002984713,0.0003654053,0.001717005,0.8973935,0.001244001,0.05775512,0.00002774057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789544,0.003596408,0.004378777,0.001466005,0.000180581,0.00002442463,0.001128028,0.0007605378,0.009510796],"genre_scores_gemma":[0.9937815,0.0006553893,0.000566905,0.0001897252,0.00001375303,0.00001200145,0.0003515898,0.00007859898,0.004350603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004923842,"threshold_uncertainty_score":0.01647192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06947623042818749,"score_gpt":0.4332863786539151,"score_spread":0.3638101482257277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}