{"id":"W4405973450","doi":"10.1080/10408363.2024.2431853","title":"Genetic variants of accessory proteins and G proteins in human genetic disease","year":2025,"lang":"en","type":"review","venue":"Critical Reviews in Clinical Laboratory Sciences","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Toronto Western Hospital","funders":"H. Lundbeck A/S; Lundbeckfonden","keywords":"Biology; Genetics; Computational biology; Human proteins; Genetic variants; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004245776,0.0004176637,0.00368235,0.0004680714,0.00009102034,0.00005361234,0.0004616651,0.0003646419,0.0001684639],"category_scores_gemma":[0.04766947,0.0002899212,0.0003609326,0.002027822,0.002218792,0.0001133337,0.0001985227,0.0007563715,0.00002272101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005843276,"about_ca_system_score_gemma":0.002572087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001007825,"about_ca_topic_score_gemma":0.000009508253,"domain_scores_codex":[0.9929449,0.001777948,0.003288675,0.00106205,0.0004614909,0.0004649478],"domain_scores_gemma":[0.9949163,0.003232237,0.000409015,0.000703839,0.0001697627,0.000568822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002562936,0.001235859,0.03635629,0.1631013,0.00002957323,0.0001693196,0.00001346887,1.831445e-7,0.000005977111,0.004275523,0.0002165388,0.7945703],"study_design_scores_gemma":[0.001078627,0.0009402108,0.0871681,0.2584683,0.001411183,0.000005248757,0.00001661551,0.00003135041,0.00000183241,0.002646083,0.6475357,0.0006966874],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001984437,0.9930815,0.00002518016,0.0001531725,0.000262451,0.003505427,0.00006265649,0.00001727949,0.0009079114],"genre_scores_gemma":[0.0006257765,0.9941635,0.003745917,0.0005237028,0.0001474141,0.0006887668,0.000005526978,0.00001645479,0.00008292212],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7938736,"threshold_uncertainty_score":0.9999553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1682206344710854,"score_gpt":0.4985984067955002,"score_spread":0.3303777723244148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}