{"id":"W4405980029","doi":"10.1101/2024.12.23.630117","title":"Click-linking: a cell-compatible protein crosslinking method based on click chemistry","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Click chemistry; Proteome; Chemistry; Interactome; Cycloaddition; Combinatorial chemistry; Mass spectrometry; Biophysics; Biochemistry; Chromatography; Catalysis; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.0008638448,0.001358795,0.001065067,0.0001594098,0.0004670627,0.0008407851,0.001609326,0.001797798,0.0009536194],"category_scores_gemma":[0.000218372,0.001556419,0.0006430582,0.0007887464,0.0001974742,0.00007006244,0.001198875,0.004018672,0.0003419137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000700183,"about_ca_system_score_gemma":0.001340545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000450737,"about_ca_topic_score_gemma":7.045091e-7,"domain_scores_codex":[0.9939613,0.00007274914,0.001249913,0.002727265,0.0008821769,0.001106573],"domain_scores_gemma":[0.9942567,0.0002887592,0.0008547971,0.003619578,0.0004205352,0.0005595815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005252576,0.0005209761,0.0003519503,0.007879375,0.0001274603,0.00008084461,0.00001312667,0.001099982,0.9892147,0.0002146656,0.0004386081,0.000005738505],"study_design_scores_gemma":[0.0006897458,0.00001270247,0.00008290196,0.003098968,0.0002366215,4.694557e-8,0.000005302997,0.01491717,0.9593758,0.00004668554,0.02002358,0.001510464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881415,0.0007343317,0.002343815,0.0006482365,0.0003663924,0.0009044356,0.001158024,0.002248477,0.003454768],"genre_scores_gemma":[0.9794866,0.000026152,0.01586405,0.0002578867,0.001734064,0.00181661,0.00001211438,0.0004298366,0.0003727032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02983894,"threshold_uncertainty_score":0.9999596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01725250718021915,"score_gpt":0.2603115871532707,"score_spread":0.2430590799730515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}