{"id":"W4405985547","doi":"10.1016/j.neurom.2024.09.052","title":"IS043 DEEP BRAIN STIMULATION OF THE NUCLEUS ACCUMBENS IN THE TREATMENT OF SEVERE ALCOHOL USE DISORDER: A PHASE I PILOT TRIAL","year":2025,"lang":"en","type":"article","venue":"Neuromodulation Technology at the Neural Interface","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre","funders":"","keywords":"Nucleus accumbens; Deep brain stimulation; Stimulation; Brain stimulation reward; Alcohol use disorder; Phase (matter); Alcohol; Psychology; Brain stimulation; Medicine; Neuroscience; Psychiatry; Internal medicine; Chemistry; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007088431,0.0002115279,0.0003404163,0.0001550195,0.0001362047,0.00001155095,0.0002915768,0.0001397179,0.00004235559],"category_scores_gemma":[0.0003507615,0.0001011237,0.0001565337,0.0007331651,0.0003058713,0.00006778471,0.0001088967,0.000235056,0.00000377231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006031408,"about_ca_system_score_gemma":0.00001799418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006820916,"about_ca_topic_score_gemma":0.0002236351,"domain_scores_codex":[0.9985408,0.0002739708,0.000472383,0.000323684,0.0001921594,0.0001970205],"domain_scores_gemma":[0.9983925,0.0005526561,0.0002313262,0.0007548051,0.00005264435,0.00001602787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1325725,0.0368198,0.3391168,0.0001463293,0.0007961442,0.000119443,0.002878501,0.03767128,0.2471251,0.00371503,0.001831201,0.1972079],"study_design_scores_gemma":[0.2239402,0.04748598,0.5786328,0.0001564209,0.00101187,0.0001182325,0.0004753877,0.05982986,0.07059579,0.01235752,0.00494905,0.0004468611],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760766,0.0001720095,0.00006888628,0.02090869,0.0002035024,0.002395298,0.00002415452,0.0000548391,0.00009604304],"genre_scores_gemma":[0.9984891,0.00004971172,0.00001408707,0.0008835067,0.000009149931,0.00009473208,0.00001027719,0.00001354573,0.000435915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.239516,"threshold_uncertainty_score":0.4123704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04964088851824655,"score_gpt":0.3504739633391515,"score_spread":0.300833074820905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}