{"id":"W4405986701","doi":"10.1038/s41467-024-55597-w","title":"Single-cell RNA sequencing identifies CXADR as a fate determinant of the placental exchange surface","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Children's Hospital Research Institute; Directorate for Biological Sciences; Research Councils UK; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; National Institute for Health and Care Research; Canada Research Chairs; Biotechnology and Biological Sciences Research Council; Department of Health and Social Care; Government of Canada","keywords":"Lineage (genetic); Trophoblast; Biology; Syncytiotrophoblast; Placenta; Cell biology; Stem cell; Progenitor cell; Cellular differentiation; Cell; RNA; Cell lineage; Genetics; Gene; Fetus; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001066217,0.0001146908,0.0001310518,0.000208957,0.0001430041,0.0003650987,0.0001201348,0.0001776099,0.0005208188],"category_scores_gemma":[0.0001638797,0.0001206952,0.0001241067,0.0001066185,0.0001982502,0.0001461983,0.0001278362,0.0002782038,0.0002710047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000189706,"about_ca_system_score_gemma":0.0001465166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006482833,"about_ca_topic_score_gemma":0.001794622,"domain_scores_codex":[0.9999382,0.000004998226,0.00000311979,0.0000256676,0.00001746617,0.00001047644],"domain_scores_gemma":[0.9999,0.00003051756,0.00002761398,0.0000152812,0.00001130761,0.00001528566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001149846,9.952205e-7,0.0003807167,0.000006908885,0.000001119324,0.00002000785,0.000009565564,0.00005600119,0.9985988,0.000127986,0.00001348972,0.0007729442],"study_design_scores_gemma":[0.000003722998,0.00004856239,0.02971741,0.000006824165,0.00001211916,0.0002237296,0.000071294,0.003841972,0.962869,0.0002933025,0.002905033,0.00000700811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792347,0.0008100066,0.0169899,0.00007294492,0.0000202117,0.00001621339,0.0009931249,0.000161498,0.001701544],"genre_scores_gemma":[0.9836197,0.0007105299,0.01180481,0.00007075064,0.000009420884,0.00003235184,0.001131726,0.00007811004,0.002542624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006482833,"threshold_uncertainty_score":0.001742363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01962564044698788,"score_gpt":0.2706450391015743,"score_spread":0.2510193986545864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}