{"id":"W4405986701","doi":"10.1038/s41467-024-55597-w","title":"Single-cell RNA sequencing identifies CXADR as a fate determinant of the placental exchange surface","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Children's Hospital Research Institute; Directorate for Biological Sciences; Research Councils UK; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; National Institute for Health and Care Research; Canada Research Chairs; Biotechnology and Biological Sciences Research Council; Department of Health and Social Care; Government of Canada","keywords":"Lineage (genetic); Trophoblast; Biology; Syncytiotrophoblast; Placenta; Cell biology; Stem cell; Progenitor cell; Cellular differentiation; Cell; RNA; Cell lineage; Genetics; Gene; Fetus; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001299397,0.0001152009,0.0001149684,0.00002941917,0.0002337504,0.00002553916,0.001008723,0.0002510466,0.000005233803],"category_scores_gemma":[0.00008575789,0.0000933533,0.0001209921,0.0001788272,0.000187683,0.000004958453,0.0004230077,0.0003486765,0.00000229341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003913687,"about_ca_system_score_gemma":0.0001171175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001023607,"about_ca_topic_score_gemma":0.001141608,"domain_scores_codex":[0.9992816,0.0001192535,0.0002001312,0.0001667409,0.00009465763,0.0001375665],"domain_scores_gemma":[0.998428,0.00005015502,0.0001004024,0.001281984,0.0001145673,0.00002489728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001876546,0.00009504041,0.001644443,0.00003250299,0.00002451572,2.53311e-7,0.0001729244,0.00001627987,0.9962689,0.0001813146,0.001087794,0.000457302],"study_design_scores_gemma":[0.0003008252,0.00003644713,0.0008159412,0.00006878463,0.00004009604,0.000003857479,0.0002244826,0.0001412365,0.9628537,0.00007746365,0.03532957,0.000107578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769746,0.01150364,0.0001116667,0.0007971535,0.0004023831,0.0002249899,0.00004675587,0.00001382002,0.009925004],"genre_scores_gemma":[0.995544,0.0007599366,0.0007871146,0.0003823291,0.00002099291,0.000007893856,0.00006711327,0.00001212985,0.002418517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03424177,"threshold_uncertainty_score":0.3806837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01962564044698788,"score_gpt":0.2706450391015743,"score_spread":0.2510193986545864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}