{"id":"W4405987255","doi":"10.1093/noajnl/vdae145","title":"Clinical integration and application of the 2022 WHO pituitary tumor classification","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Pituitary Gland Disorders and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Pituitary tumors; Craniopharyngioma; Biology; MEN1; Endocrine system; Epigenetics; Cell type; Pituitary gland; Pituitary neoplasm; Neuroendocrine differentiation; Pathology; Hormone; Cancer research; Cell; Medicine; Endocrinology; Gene; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001202821,0.00007637143,0.0002164688,0.00004690136,0.00008255512,0.00000228078,0.00006458109,0.00006124836,0.000006038232],"category_scores_gemma":[0.0001980227,0.00004844692,0.00005302469,0.0001635073,0.000203084,0.00007591845,0.00003309625,0.0001486685,0.000002265753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002327504,"about_ca_system_score_gemma":0.00008952367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001125768,"about_ca_topic_score_gemma":0.00007183611,"domain_scores_codex":[0.9992524,0.00009950492,0.0002749821,0.0002183805,0.00007496496,0.00007971176],"domain_scores_gemma":[0.9993076,0.000266338,0.0001327333,0.0002110289,0.00005350875,0.00002881025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002552981,0.0003212541,0.6777245,0.00003412086,0.00002715056,0.000003009163,0.00004075949,0.000002630229,0.005788391,0.003577108,0.0007462939,0.3114795],"study_design_scores_gemma":[0.001800835,0.0004803338,0.9378476,0.00003533353,0.0001434195,0.00001601511,0.0002383577,0.001054073,0.001066662,0.004903997,0.05236641,0.00004697395],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741501,0.004029693,0.00291715,0.007179883,0.0005545439,0.0008612971,0.00001008399,0.00003291381,0.01026436],"genre_scores_gemma":[0.9965106,0.001218762,0.0003168703,0.001707587,0.00003627261,0.00006898258,0.00001668536,0.000003951785,0.0001203123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3114325,"threshold_uncertainty_score":0.1975608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01632092754940955,"score_gpt":0.3515106366699181,"score_spread":0.3351897091205085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}