{"id":"W4406002904","doi":"10.1186/s13195-024-01665-8","title":"Cerebrospinal fluid β2-microglobulin promotes the tau pathology through microglia–astrocyte communication in Alzheimer's disease","year":2025,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Cerebrospinal fluid; Glial fibrillary acidic protein; Neurodegeneration; Medicine; Microglia; Pathology; Alzheimer's disease; Pathogenesis; Tau protein; Neurology; Astrocyte; Amyloid beta; Internal medicine; Disease; Immunohistochemistry; Central nervous system; Psychiatry; Inflammation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001818609,0.0005012121,0.0006332804,0.0005057738,0.0008972167,0.0001974973,0.001157423,0.0002255241,0.0003413437],"category_scores_gemma":[0.0002015043,0.0003526614,0.0003280679,0.001629272,0.001600194,0.0003479248,0.0005440936,0.001451441,0.0003950476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001965849,"about_ca_system_score_gemma":0.001680614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009561,"about_ca_topic_score_gemma":0.00009708488,"domain_scores_codex":[0.9935905,0.001926539,0.0006921926,0.0009698273,0.00118911,0.001631774],"domain_scores_gemma":[0.9956281,0.0006844161,0.000111255,0.002316197,0.0007269298,0.0005331266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.05603826,0.02357501,0.3270066,0.0002841663,0.1157888,0.005045577,0.007475072,0.00003726032,0.02040428,0.01714372,0.07770874,0.3494925],"study_design_scores_gemma":[0.03876289,0.005535288,0.6855782,0.001990464,0.004965873,0.0002765189,0.00346253,0.000888053,0.1162027,0.0367636,0.1035741,0.001999791],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3778976,0.5859436,0.00003316546,0.02817332,0.0001230636,0.00539535,0.00008894278,0.0001462764,0.002198598],"genre_scores_gemma":[0.9751967,0.0207715,0.0007273699,0.001338534,0.0001323337,0.001305961,0.0002894143,0.00007898874,0.0001592163],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.597299,"threshold_uncertainty_score":0.9998925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08315557181781294,"score_gpt":0.4031671520684553,"score_spread":0.3200115802506424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}