{"id":"W4406010846","doi":"10.2337/dc24-1773","title":"Tirzepatide Associated With Reduced Albuminuria in Participants With Type 2 Diabetes: Pooled Post Hoc Analysis From the Randomized Active- and Placebo-Controlled SURPASS-1–5 Clinical Trials","year":2025,"lang":"en","type":"article","venue":"Diabetes Care","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institutes of Health; Gilead Sciences; National Institute on Minority Health and Health Disparities; Centers for Disease Control and Prevention; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; National Institute of Diabetes and Digestive and Kidney Diseases; Amgen; National Heart, Lung, and Blood Institute; Pfizer; Novo Nordisk; Sanofi; Abbott Laboratories","keywords":"Medicine; Post-hoc analysis; Albuminuria; Type 2 diabetes; Placebo; Population; Internal medicine; Renal function; Diabetes mellitus; Creatinine; Urology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01442712,0.002898306,0.01073105,0.0008393471,0.0003244411,0.001960706,0.0009414837,0.001496195,0.004590507],"category_scores_gemma":[0.01347848,0.001169833,0.02466267,0.0009281217,0.000665565,0.001232325,0.001121919,0.002048062,0.0003878958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006623113,"about_ca_system_score_gemma":0.00100449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001381817,"about_ca_topic_score_gemma":0.003095184,"domain_scores_codex":[0.9889522,0.00740764,0.001318092,0.001182169,0.0006538101,0.0004861224],"domain_scores_gemma":[0.9926621,0.003840956,0.001879796,0.0007930604,0.0005510506,0.0002730314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.6526672,0.0003718978,0.004436627,0.008941757,0.3221247,0.0001091312,0.00006406002,0.0008761042,0.00169704,0.00007965574,0.0007590243,0.007872844],"study_design_scores_gemma":[0.3102929,0.02612708,0.03939675,0.0007075393,0.6176131,0.0001696028,0.0001079842,0.002054356,0.001159975,0.0003225723,0.001948153,0.00009997276],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8686883,0.1091342,0.005317487,0.0005856481,0.001874616,0.004552397,0.006739765,0.0004455271,0.002661973],"genre_scores_gemma":[0.9841689,0.007916654,0.001894647,0.0004354081,0.000411585,0.001988936,0.001964979,0.00006467941,0.001154196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01442712,"threshold_uncertainty_score":0.07629883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0273082124883336,"score_gpt":0.3413970067044683,"score_spread":0.3140887942161347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}