{"id":"W4406025948","doi":"10.3390/cells14010045","title":"TGFβ1 Restores Energy Homeostasis of Human Trophoblast Cells Under Hyperglycemia In Vitro by Inducing PPARγ Expression, AMPK Activation, and HIF1α Degradation","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Université de Montréal; Institut National de la Recherche Scientifique; Université du Québec à Trois-Rivières; Université du Québec","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Trophoblast; GLUT1; AMPK; Biology; Internal medicine; Endocrinology; Cell biology; Glycolysis; Carbohydrate metabolism; Glucose uptake; Chemistry; Placenta; Metabolism; Protein kinase A; Kinase; Insulin; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001758171,0.0003370375,0.0003013484,0.0002712888,0.000161753,0.0002831805,0.0001180989,0.0001825505,0.00109262],"category_scores_gemma":[0.0001082876,0.0001669196,0.0003597339,0.000216263,0.0001331465,0.0001325628,0.0001912241,0.0006955134,0.0003040142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001606018,"about_ca_system_score_gemma":0.0002474826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00120593,"about_ca_topic_score_gemma":0.001487568,"domain_scores_codex":[0.9998845,0.00002627724,0.0000178357,0.00001777396,0.00002722467,0.00002642939],"domain_scores_gemma":[0.9999368,0.00001468784,0.0000126655,0.00001274173,0.000007765166,0.00001533567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000705848,0.0001193129,0.0004714213,0.00007885693,0.0000141599,0.0001458787,0.00009225264,0.0000908521,0.9956443,0.00007843759,0.0001259021,0.002432812],"study_design_scores_gemma":[0.0001371225,0.001357756,0.01248284,0.00002600722,0.0000668532,0.0004545718,0.0001806061,0.001087494,0.9767699,0.0001162578,0.007311883,0.000008794499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904956,0.004803041,0.001296906,0.0002227835,0.0001056176,0.00003957542,0.0006593011,0.00005073328,0.002326526],"genre_scores_gemma":[0.9894549,0.00333777,0.001842688,0.0001799243,0.00003065702,0.00007465449,0.002137495,0.00002443254,0.002917515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00120593,"threshold_uncertainty_score":0.003655136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006101061520613759,"score_gpt":0.228604558481576,"score_spread":0.2225034969609622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}