{"id":"W4406025948","doi":"10.3390/cells14010045","title":"TGFβ1 Restores Energy Homeostasis of Human Trophoblast Cells Under Hyperglycemia In Vitro by Inducing PPARγ Expression, AMPK Activation, and HIF1α Degradation","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Université de Montréal; Institut National de la Recherche Scientifique; Université du Québec à Trois-Rivières; Université du Québec","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Trophoblast; GLUT1; AMPK; Biology; Internal medicine; Endocrinology; Cell biology; Glycolysis; Carbohydrate metabolism; Glucose uptake; Chemistry; Placenta; Metabolism; Protein kinase A; Kinase; Insulin; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008957877,0.0001443058,0.0002011195,0.000100938,0.00006241474,0.00001897354,0.0001194913,0.0001689822,0.00001611333],"category_scores_gemma":[0.00001725676,0.0001421258,0.00003993714,0.0001513869,0.00006560337,0.000009760824,0.00006862243,0.00007347988,5.424636e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002756088,"about_ca_system_score_gemma":0.0000653825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001701713,"about_ca_topic_score_gemma":0.00003241657,"domain_scores_codex":[0.9990622,0.0000627372,0.0002608616,0.0003295682,0.0001035432,0.0001810452],"domain_scores_gemma":[0.9994836,0.00001975336,0.0001193465,0.0002650263,0.00006484464,0.00004742269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007447696,0.00004974736,0.0001114279,0.00003255948,0.00001716882,1.333964e-7,0.00004871634,0.00005135122,0.9776071,0.00006904356,0.01055127,0.01138703],"study_design_scores_gemma":[0.000614023,0.00003597968,0.0005035927,0.00004577583,0.00001312922,9.123472e-8,0.0001757065,0.000004586425,0.9645366,0.0002318016,0.03370848,0.0001302503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743925,0.02420209,0.0008464938,0.00001853978,0.0001405816,0.00007955412,0.00002712453,0.00000572741,0.0002873286],"genre_scores_gemma":[0.9925964,0.006014223,0.0002736708,0.0002896633,0.00006879621,0.00002020489,0.0001543242,0.00001644357,0.0005662683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02315721,"threshold_uncertainty_score":0.5795724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006101061520613759,"score_gpt":0.228604558481576,"score_spread":0.2225034969609622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}