{"id":"W4406027918","doi":"10.1126/sciadv.ads5963","title":"Transcriptional regulation of adipocyte lipolysis by IRF2BP2","year":2025,"lang":"en","type":"article","venue":"Science Advances","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of Ottawa; American Heart Association","keywords":"Lipolysis; Adipocyte; Lipase; Biology; Chromatin immunoprecipitation; Internal medicine; Adipose tissue; Endocrinology; Catabolism; Energy homeostasis; Hormone-sensitive lipase; Chemistry; Biochemistry; Enzyme; Gene expression; Metabolism; Gene; Medicine; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002554595,0.0005142941,0.0002831608,0.0003057786,0.0002618668,0.000449534,0.0002438642,0.0003220374,0.003107698],"category_scores_gemma":[0.0001530416,0.0002369163,0.0004931705,0.0001967517,0.0002815121,0.0002147667,0.0004462278,0.0006920079,0.001153175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003646219,"about_ca_system_score_gemma":0.0001932025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006133956,"about_ca_topic_score_gemma":0.0008710477,"domain_scores_codex":[0.9997506,0.00003727282,0.0000141959,0.00008440922,0.00004987882,0.00006360299],"domain_scores_gemma":[0.9998977,0.00001961531,0.00002458537,0.00001722074,0.00002016441,0.0000206783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001535829,0.00002021004,0.000635871,0.00003215265,0.00000811826,0.00005956539,0.00001591665,0.0000696695,0.9967275,0.0002146293,0.0002157002,0.001847039],"study_design_scores_gemma":[0.00008068163,0.0001792616,0.03965274,0.00003067889,0.00005341719,0.0007357593,0.0001544493,0.003237288,0.9422876,0.0004836323,0.01306956,0.00003492734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9594516,0.007371661,0.01960223,0.0007174389,0.0002791589,0.00005086946,0.003515314,0.0005229943,0.008488741],"genre_scores_gemma":[0.9784805,0.001671712,0.006170619,0.0004196014,0.00005344813,0.00006320641,0.004474007,0.0001182287,0.008548814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003107698,"threshold_uncertainty_score":0.0103963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003877055020852019,"score_gpt":0.2461685382874428,"score_spread":0.2422914832665907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}