{"id":"W4406028537","doi":"10.1101/2025.01.02.631052","title":"Broad-Spectrum Antiviral Efficacy of 7-Deaza-7-Fluoro-2’-C-Methyladenosine Against Multiple Coronaviruses <i>In Vitro</i> and <i>In Vivo</i>","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Canadian Society of Microbiologists; Centre hospitalier universitaire de Québec","funders":"Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Universidade Federal de Minas Gerais; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Academia Brasileira de Ciências; National Science Council; L'Oreal USA","keywords":"In vivo; In vitro; Broad spectrum; Virology; Coronavirus disease 2019 (COVID-19); Chemistry; Biology; Pharmacology; Medicine; Biochemistry; Genetics; Combinatorial chemistry; Internal medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001274619,0.0002470349,0.0001927157,0.0001494728,0.0001093584,0.0001181366,0.0001530502,0.0002125918,0.0008958341],"category_scores_gemma":[0.00006250023,0.00007253407,0.0001735296,0.00007247544,0.0001022302,0.0001264906,0.00007042437,0.0003316955,0.0001472241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001198318,"about_ca_system_score_gemma":0.0001342743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008742986,"about_ca_topic_score_gemma":0.001013523,"domain_scores_codex":[0.999946,0.0000135462,0.00000487745,0.00001166653,0.000009520675,0.0000143851],"domain_scores_gemma":[0.9999638,0.000008677528,0.000008455796,0.000004126181,0.000005528622,0.000009468245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005138229,0.000128567,0.00009390363,0.0000405466,0.000006597144,0.00001766065,0.000009931691,0.0001637088,0.9958121,0.00003894289,0.0000572886,0.003116966],"study_design_scores_gemma":[0.00009218229,0.007121258,0.001747423,0.000007847631,0.00002724703,0.00009833458,0.00001371077,0.000914436,0.9882402,0.00001994921,0.00171155,0.000005877492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946021,0.002802355,0.0007595498,0.00003740593,0.00003246904,0.00003261396,0.0001804647,0.00003995489,0.001512978],"genre_scores_gemma":[0.9974397,0.000855525,0.0006604476,0.00002652613,0.000009062303,0.00001565189,0.0001849003,0.000004414154,0.0008037933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008958341,"threshold_uncertainty_score":0.002996862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181958881975294,"score_gpt":0.2718829553472805,"score_spread":0.2536870671497511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}