{"id":"W4406030096","doi":"10.1093/noajnl/vdae228","title":"cIMPACT-NOW update 9: Recommendations on utilization of genome-wide DNA methylation profiling for central nervous system tumor diagnostics","year":2025,"lang":"en","type":"review","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute; Great Ormond Street Institute of Child Health; Perelman School of Medicine, University of Pennsylvania; National Institutes of Health; Universitätsklinikum Heidelberg; Freie Universität Berlin; Hospital for Sick Children; Vrije Universiteit Amsterdam; Brain Tumour Charity; University of Toronto; Brigham and Women's Hospital; Cancer Research UK; University College London; Massachusetts General Hospital; St. Jude Children's Research Hospital; National Institute for Health and Care Research; Deutschen Konsortium für Translationale Krebsforschung; Great Ormond Street Hospital for Children; Amsterdam University Medical Centers; Humboldt-Universität zu Berlin; Universitätsspital Basel; Deutsches Krebsforschungszentrum; York University; Universität Zürich; University of Pennsylvania","keywords":"Profiling (computer programming); DNA methylation; Computational biology; Genome; Biology; Central nervous system; Bioinformatics; Medicine; Genetics; Neuroscience; Computer science; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03961078,0.001751382,0.002346143,0.009753752,0.001116825,0.004627782,0.01086784,0.01216267,0.01494062],"category_scores_gemma":[0.1139169,0.001790292,0.004468221,0.006483728,0.001858325,0.004686618,0.004780249,0.01148902,0.0185056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004588825,"about_ca_system_score_gemma":0.01881146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03876764,"about_ca_topic_score_gemma":0.04205362,"domain_scores_codex":[0.977988,0.008845801,0.00592079,0.001011494,0.00514556,0.001088317],"domain_scores_gemma":[0.8633181,0.04884203,0.01054545,0.004814303,0.06602534,0.006454835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000127432,0.0000755399,0.001634133,0.002158917,0.00009463257,0.0002134731,0.0001960855,0.0006297879,0.0006399867,0.001751112,0.8728021,0.1196768],"study_design_scores_gemma":[0.0001102048,0.00007504017,0.003453932,0.006444594,0.0002496354,0.0003891073,0.0001567563,0.0003812065,0.0007323336,0.003004219,0.984922,0.00008110806],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.002853671,0.128501,0.07326435,0.560213,0.04674404,0.005292534,0.07464533,0.01224244,0.09624372],"genre_scores_gemma":[0.01181122,0.170579,0.3255497,0.290103,0.01655576,0.009458337,0.1140433,0.004090099,0.05780962],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.03961078,"threshold_uncertainty_score":0.2094844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05412338250434129,"score_gpt":0.3826544957463135,"score_spread":0.3285311132419723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}