{"id":"W4406034318","doi":"10.1021/acs.jmedchem.4c01778","title":"Novel Orthosteric/Allosteric Ligands of Cannabinoid Receptors: An Unexpected Pharmacological Profile","year":2025,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Ministero dell’Istruzione, dell’Università e della Ricerca; University of Saskatchewan","keywords":"Chemistry; Allosteric regulation; Cannabinoid receptor; Cannabinoid; Receptor; Pharmacology; Neuroscience; Stereochemistry; Biochemistry; Agonist; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001814511,0.0003162222,0.0004005423,0.0002421894,0.0001529395,0.000245409,0.0002615188,0.0001979578,0.001698519],"category_scores_gemma":[0.0001248903,0.0001164496,0.0002238635,0.0001672481,0.0001970307,0.0001999747,0.0002396937,0.0006197672,0.0004805528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462472,"about_ca_system_score_gemma":0.0001500464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000248546,"about_ca_topic_score_gemma":0.001165853,"domain_scores_codex":[0.9999323,0.00001286872,0.00000590317,0.00001282567,0.00001764154,0.00001846062],"domain_scores_gemma":[0.9999498,0.000008822516,0.00001000378,0.000008153629,0.000008928582,0.00001420258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003345317,0.0001266498,0.0002176915,0.0002342126,0.00001769634,0.0002091587,0.0000586814,0.0003714226,0.9775037,0.0008022414,0.0002335567,0.01989046],"study_design_scores_gemma":[0.0001821596,0.004952623,0.003970254,0.0000489247,0.0001437793,0.002157442,0.00007442574,0.001953029,0.9671834,0.0003758364,0.01890411,0.00005398701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656784,0.009391268,0.01233273,0.0003219225,0.00009174799,0.0002361981,0.0006557612,0.0002217672,0.01107018],"genre_scores_gemma":[0.9782411,0.005497756,0.01007893,0.0003581836,0.00005097048,0.00007623868,0.0005450471,0.00003039305,0.005121394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001698519,"threshold_uncertainty_score":0.005682111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01862068873940654,"score_gpt":0.3369466733959591,"score_spread":0.3183259846565526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}