{"id":"W4406037878","doi":"10.3892/mmr.2025.13429","title":"Adiponectin targets the AMPK/mTOR signaling pathway to alleviate cognitive impairment in epilepsy","year":2025,"lang":"en","type":"article","venue":"Molecular Medicine Reports","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hebei North University","keywords":"Morris water navigation task; AMPK; Adiponectin; PI3K/AKT/mTOR pathway; Epilepsy; Adiponectin receptor 1; Endocrinology; Hippocampus; Neuroscience; Biology; Internal medicine; Protein kinase A; Medicine; Signal transduction; Phosphorylation; Cell biology; Insulin resistance","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001201332,0.0003213229,0.0002381173,0.0001896263,0.0001109652,0.000157659,0.00009756113,0.0001340481,0.0007533341],"category_scores_gemma":[0.00006374994,0.00008758238,0.0001718471,0.0001936054,0.0001510846,0.00009943214,0.0001619256,0.0002886796,0.0001219317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001450677,"about_ca_system_score_gemma":0.0001377635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004448635,"about_ca_topic_score_gemma":0.001168928,"domain_scores_codex":[0.9999623,0.000007627385,0.00000622706,0.000005591821,0.000006033655,0.00001220697],"domain_scores_gemma":[0.9999764,0.000002472803,0.00001086406,0.000001982309,0.000002663886,0.000005675038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01822633,0.002751564,0.05179323,0.001333451,0.0005406053,0.002266581,0.0001989687,0.0006536059,0.7225364,0.0008155789,0.003160285,0.1957233],"study_design_scores_gemma":[0.005375572,0.03383185,0.6410974,0.0002004041,0.001408496,0.006969396,0.0006820739,0.00486808,0.2771293,0.00127326,0.02709502,0.00006915974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874586,0.01011741,0.0008057668,0.0002233231,0.00004921419,0.00004464806,0.0001192975,0.00004646127,0.001135267],"genre_scores_gemma":[0.9923003,0.005770487,0.0005774188,0.000176457,0.00003335366,0.00004593995,0.000168641,0.000003532455,0.0009238512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007533341,"threshold_uncertainty_score":0.002520204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01347555717210703,"score_gpt":0.2762312774950329,"score_spread":0.2627557203229259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}