{"id":"W4406038911","doi":"10.1111/andr.13828","title":"Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies","year":2025,"lang":"en","type":"review","venue":"Andrology","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Fundação para a Ciência e a Tecnologia; Centre National de la Recherche Scientifique; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Université Grenoble Alpes","keywords":"Asthenozoospermia; Capacitation; Sperm; Biology; Flagellum; Sperm motility; Hyperactivation; Male infertility; Cell biology; Infertility; Motility; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005739352,0.0007616008,0.001231881,0.002987605,0.0002595799,0.0008329644,0.0007227613,0.0007870147,0.005488132],"category_scores_gemma":[0.001223875,0.0001869654,0.0005873711,0.00189594,0.000343147,0.001191615,0.000499857,0.001093867,0.001270805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005653567,"about_ca_system_score_gemma":0.0009687102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001728248,"about_ca_topic_score_gemma":0.00270861,"domain_scores_codex":[0.9997565,0.00004970362,0.00006338688,0.00004457324,0.00006241917,0.00002340973],"domain_scores_gemma":[0.9994026,0.0002414481,0.00009584249,0.00001463277,0.0001845486,0.00006091626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001486655,0.00005985337,0.003972915,0.007576402,0.0001682046,0.001579733,0.00009535142,0.0003139081,0.000901295,0.001604927,0.07945861,0.9041202],"study_design_scores_gemma":[0.00006763457,0.0001703677,0.009935388,0.014212,0.000967081,0.02142218,0.0002762243,0.0003233023,0.0005704434,0.003510891,0.9484797,0.00006493006],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006565891,0.994738,0.0005425356,0.001649075,0.0004374547,0.00001041897,0.0001732431,0.00004863914,0.001743947],"genre_scores_gemma":[0.004671977,0.9901122,0.001336813,0.0009704663,0.001274322,0.00002374665,0.0006234879,0.00001033228,0.0009766167],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005488132,"threshold_uncertainty_score":0.0183596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03948385531451119,"score_gpt":0.3703065862505838,"score_spread":0.3308227309360726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}