{"id":"W4406038911","doi":"10.1111/andr.13828","title":"Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies","year":2025,"lang":"en","type":"review","venue":"Andrology","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Fundação para a Ciência e a Tecnologia; Centre National de la Recherche Scientifique; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Université Grenoble Alpes","keywords":"Asthenozoospermia; Capacitation; Sperm; Biology; Flagellum; Sperm motility; Hyperactivation; Male infertility; Cell biology; Infertility; Motility; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009549974,0.0002742886,0.001140058,0.0001945787,0.00007021212,0.00001929008,0.00006438069,0.0003980325,0.0001331782],"category_scores_gemma":[0.00002471212,0.0002032032,0.0002195002,0.0001132003,0.0001161515,0.00001569027,0.00008300542,0.0003976445,0.000100615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000264132,"about_ca_system_score_gemma":0.0000957521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009971103,"about_ca_topic_score_gemma":0.0000132923,"domain_scores_codex":[0.998527,0.000151741,0.0005200762,0.0004882535,0.00009766398,0.0002152562],"domain_scores_gemma":[0.9992663,0.00009336314,0.0001485363,0.0003829342,0.00002594064,0.00008294188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001947343,0.000158293,0.0004727749,0.006055707,0.0005713442,0.0006977603,0.000004992404,2.72012e-7,2.918158e-8,0.003460429,0.002941262,0.9856176],"study_design_scores_gemma":[0.0006216118,0.001476064,0.003199838,0.002761632,0.003569023,0.0003011656,0.00001027871,0.00000151085,4.414963e-8,0.0003473968,0.98755,0.0001615016],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001282121,0.9885142,0.00001956974,0.00004994788,0.0005153461,0.0007551863,0.000008929373,0.00005370013,0.008801023],"genre_scores_gemma":[0.0004487612,0.9975363,0.0001085096,0.0006685473,0.0001911106,0.0000499948,0.0001585542,0.00002378782,0.0008144327],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9854562,"threshold_uncertainty_score":0.8286387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03948385531451119,"score_gpt":0.3703065862505838,"score_spread":0.3308227309360726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}